吸入麻醉药敏感性的线粒体机制研究进展  

Research progress on mitochondrial mechanisms of sensitivity toinhalational anesthetics

作　　者：程思静 魏义勇 王海英 CHENG Sijing;WEI Yiyong;WANG Haiying(Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China;不详)

机构地区：[1]遵义医科大学附属医院麻醉科,贵州遵义563000 [2]深圳市龙岗区妇幼保健院,广东深圳518000

出　　处：《中国临床研究》2024年第8期1168-1171,共4页Chinese Journal of Clinical Research

基　　金：国家自然科学基金(8186020335);遵义市联合基金[遵市科合HZ(2021)84号];贵州省科技厅科技计划项目(黔科合基础-ZK[2022]一般664);遵义医科大学博士启动基金项目[院字(2021)3号]。

摘　　要：实验动物和人均对吸入麻醉药存在敏感性差异,这关系到全身麻醉期间的麻醉深度及患者的围术期安全。研究吸入麻醉药敏感性的机制,有助於改善患者术后结局。线粒体是机体能量代谢的重要细胞器,线粒体结构与功能的变化参与了吸入麻醉药敏感性的机制。目前的研究表明,线粒体相关基因突变、代谢通路、离子通道等参与了吸入麻醉药敏感性的机制。鉴于此,本文从吸入麻醉药敏感性概述、线粒体相关基因突变、代谢通路、离子通道等几个方面的研究进展进行综述。Experimental animals and people have different sensitivity to inhalational anesthetics,which is related to the depth of anesthesia during general anesthesia and the perioperative safety of patients.Studying the mechanism of inhalational anesthetics sensitivity is helpful to improve the postoperative outcomes of patients.Mitochondria are important organelles for energy metabolism in the body,and changes in mitochondrial structure and function are involved in the mechanism of inhalational anesthetics sensitivity.Current research indicates that mitochondrial related gene mutations,metabolic pathways,ion channels,and other factors are involved in the mechanism of inhalational anesthetics sensitivity.In view of this,this article reviews the research progress in several aspects such as inhalational anesthetics sensitivity overview,mitochondrial related gene mutations,metabolic pathways,ion channels,etc.

关 键 词：吸入麻醉药 线粒体 敏感性 能量代谢 

分 类 号：R614.2[医药卫生—麻醉学]