何首乌延缓衰老机制探析  

Exploration of the Mechanism of Heshouwu(Polygoni Multiflori Radix)Delaying Aging

作　　者：王重阳 李奇玮[2] 姜北[1] 梁华[1] WANG Chongyang;LI Qiwei;JIANG Bei;LIANG Hua(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China;The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第四医院,黑龙江哈尔滨150001

出　　处：《辽宁中医药大学学报》2024年第9期177-181,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：黑龙江省中医药科研项目(GY2022-02)。

摘　　要：何首乌始载于宋代《开宝本草》,是临床常用的大宗药材之一。何首乌素有延缓衰老之灵药的美称,具有补肝肾、益精血、补虚损、黑须发等功效,被广泛用于预防和治疗衰老等相关疾病。何首乌的主要活性成分是二苯乙烯苷、多糖、蒽醌类等,具有增强免疫、抗氧化、延缓衰老、抗炎、降血脂及神经保护等药理作用。该文综述了何首乌对皮肤系统、阿尔茨海默病、动脉粥样硬化及帕金森病等衰老相关疾病的影响以及延缓衰老的作用机制,以期为何首乌在延缓老化方向的应用奠定理论基础。Heshouwu(Polygoni Multiflori Radix)was first recorded in the Kaibao Materia Medica of the Song Dynasty and is one of the commonly used bulk medicinal herbs in clinical practice.Heshouwu(Polygoni Multiflori Radix)is known as a spiritual medicine that can delay aging.It has the effects of tonifying the liver and kidney,nourishing essence and blood,tonifying deficiency and damage,and treating black beard and hair.It is widely used to prevent and treat age-related diseases.The main active ingredients of Heshouwu(Polygoni Multiflori Radix)are stilbene glycosides,polysaccharides,anthraquinones,etc.,which have pharmacological effects such as enhancing immunity,antioxidation,delaying aging,antiinflammatory,lipid-lowering,and neuroprotective effects.This article reviewed the effects of Heshouwu(Polygoni Multiflori Radix)on skin system,Alzheimer's disease,atherosclerosis,Parkinson's disease and other aging related diseases,as well as the mechanism of anti-aging,in order to lay a theoretical foundation for the application of Heshouwu(Polygoni Multiflori Radix)in anti-aging.

关 键 词：何首乌 二苯乙烯苷 多糖 延缓衰老 抗氧化 免疫调节 

分 类 号：R282.71[医药卫生—中药学]