排石颗粒对气滞血瘀型输尿管结石患者行输尿管镜下钬激光碎石术后排石效果  

Effects of Paishi Granules after holmium laser lithotripsy under ureteroscopy in patients with Qi stagna-tion and blood stasis type ureteral stones

作　　者：吴楠楠 金月娥 王佳 Wu Nannan;Jin Yue′e;Wang Jia(Department of Urology,Jinhua Traditional Chinese Medicine Hospital affiliated with Zhejiang University of Tradi-tional Chinese Medicine,Jinhua,Zhejiang 321000,China)

机构地区：[1]浙江中医药大学附属金华中医院泌尿外科,浙江金华321000

出　　处：《中国药物与临床》2024年第16期1026-1030,共5页Chinese Remedies & Clinics

摘　　要：目的探究排石颗粒对气滞血瘀型输尿管结石患者行输尿管镜下钬激光碎石术后排石效果的影响。方法2021年10月至2023年10月,选取浙江中医药大学附属金华中医院收治的120例行输尿管镜下钬激光碎石术治疗的气滞血瘀型输尿管结石患者实施前瞻性研究,按随机数字表法,分为治疗组(60例,实施口服排石颗粒治疗)、对照组(60例,实施术后常规治疗)。比较2组治疗4周后疗效与尿频尿急缓解情况、疼痛程度(VAS评分)、中医证候积分、炎性因子指标、不良反应的差异。结果治疗组治疗4周后疗效、总有效率、尿频尿急缓解情况较对照组更好(Z=2.394,χ^(2)=6.536、9.730,P<0.05)。2组VAS评分、中医证候积分的时间、组间、交互作用差异存在统计学意义(F=490.447/3885.589,14.219/6.847、26.748/22.413,P<0.05),与治疗前相比,治疗1周后2组VAS评分、中医证候积分均降低(t=17.944/33.813、10.406/31.121,P<0.05),且治疗组低于对照组(t=7.972/6.769,P<0.05)。与治疗前相比,治疗4周后2组WBC、CRP、TNF-α、IL-6均降低(t=27.004/12.904、12.917/6.571、24.855/12.028、48.111/28.561,P<0.05);且治疗组WBC、CRP、TNF-α、IL-6均低于对照组(t=21.183/11.089、39.499/4.521、10.165/11.225、13.936/16.861,P<0.05)。2组治疗期间均未发生明显不良反应。结论排石颗粒应用于行输尿管镜下钬激光碎石术后气滞血瘀型输尿管结石具有较好疗效,可有效排石,促进尿频尿急缓解,改善疼痛程度,调节炎症反应,且安全性较好。Objective To explore the stone discharge effect of Paishi Granules after Holmium laser lithotripsy under ureteroscopy in patients with Qi stagnation and blood stasis ureteral calculi.Methods From October 2021 to October 2023,a total of 120 patients were selected to conduct prospective studies who had Qi stagnation and blood stasis ureteral calculi and were treated with Holmium laser lithotripsy under ureteroscopy in our hospital.According to a method of random number table,they were divided into a treatment group(60 cases orally medicated with Paishi Granules)and a control group(60 cases treated with postoperative conventional treatment).Compare the difference in effect,the relief of frequent urination and urgency,pain(VAS score),Tradi-tional Chinese Medicine(TCM)Symptom Score,inflammatory factors,and adverse effects after 4 weeks′treatment between the two groups.Results Rank-sum test of hierarchical data showed that the efficacy,total effective rate,and relief of urinary frequency and urgency after 4 weeks of treatment were better in the treatment group than those in the control group(Z=2.394,χ^(2)=6.536,9.730,P<0.05).Repeated measures showed statistically significant differences in the time-point,between-group,and interaction comparisons of VAS scores and TCM symptom scores between the two groups(F=490.447/3885.589,14.219/6.847,26.748/22.413,P<0.05).VAS scores and TCM symptom scores were lower in both groups after 1 week′s treatment compared with those before treatment(t=17.944/33.813,10.406/31.121,P<0.05),and the scores in the treatment group were lower than those the control group(t=7.972/6.769,P<0.05).Compared with pre-treatment,WBC,CRP,TNF-α,and IL-6 were lower in both groups after 4 weeks′treatment(t=27.004/12.904,12.917/6.571,24.855/12.028,48.111/28.561,P<0.05).The dif-ferences of WBC,CRP,and IL-6 in the treatment group were smaller than that in the control group(t=21.183/11.089,39.499/4.521,10.165/11.225,13.936/16.861,P<0.05).No significant adverse reactions and side effects occurred during the t

关 键 词：排石颗粒 血瘀气滞 输尿管结石 碎石术 激光 

分 类 号：R699.4[医药卫生—泌尿科学]