Ternary NiCoTi-layered double hydroxide nanosheets as a pH-responsive nanoagent for photodynamic/chemodynamic synergistic therapy  

作　　者：Tingting Hu Zhan Zhou Jiajia Zha Gareth RWilliams Zhikang Wu Wei Zhao Weicheng Shen Hai Li Xisheng Weng Ruizheng Liang Chaoliang Tan 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering,Bejing Advanced Innovation Center for Soft Matter Science and Engineering,Bejing University of Chemical Technology,Beijing100029,China [2]College of Chemistry and Chemical Engineering,Henan Key Laboratory of Function-Oriented Porous Materials,Luoyang Normal University,Luoyang 471934,China [3]Department of Electrical Engineering,City University of Hong Kong,Hong Kong SAR 999077,China [4]UCL School of Pharmacy,University College London,London WCIN 1AX,United Kingdom [5]Institute of Advanced Materials(IAM)and Key Laboratory of Flexible Electronics(KLoFE),Nanjing Tech University(NanjingTech),Nanjing 211816,China [6]Department of Orthopedic Surgery,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China [7]Center of Super-Diamond and Advanced Films(COSDAF),City University of Hong Kong,Hong Kong SAR 999077,China [8]Shenzhen Research Institute,City University of Hong Kong,Shenzhen 518057,China

出　　处：《Fundamental Research》2024年第4期926-933,共8页自然科学基础研究（英文版）

基　　金：National Natural Science Foundation of China(21971007);the Beijing Natural Science Foundation(2212044).C.T;thanks the funding support from the National Natural Science Foundation of China(52122002 and 22005259);the Start-Up Grant(9610495)from City University of Hong Kong.

摘　　要：Combining photodynamic therapy(PDT)with chemodynamic therapy(CDT)has been proven to be a promising strategy to improve the treatment efficiency of cancer,because of the synergistic therapeutic effect arising between the two modalities.Herein,we report an inorganic nanoagent based on ternary NiCoTi-layered double hydroxide(NiCoTi-LDH)nanosheets to realize highly efficient photodynamic/chemodynamic synergistic therapy.The NiCoTi-LDH nanosheets exhibit oxygen vacancy-promoted electron-hole separation and photogenerated holeinduced O_(2)-independent reactive oxygen species(ROS)generation under acidic circumstances,realizing in situ pH-responsive PDT.Moreover,due to the effective conversion between Co^(3+)and Co^(2+)caused by photogenerated electrons,the NiCoTi-LDH nanosheets catalyze the release of hydroxyl radicals(-OH)from H_(2)O_(2)through Fenton reactions,resulting in CDT.Laser irradiation enhances the catalyzed ability of the NiCoTi-LDH nanosheets to promote the ROS generation,resulting in a better performance than TiO_(2)nanoparticles at pH 6.5.In vitro and in vivo experimental results show conclusively that NiCoTi-LDH nanosheets plus irradiation lead to efficient cell apoptosis and significant inhibition of tumor growth.This study reports a new pH-responsive inorganic nanoagent with oxygen vacancy-promoted photodynamic/chemodynamic synergistic performance,offering a potentially appealing clinical strategy for selective tumor elimination.

关 键 词：Layereddouble hydroxides Photodynamic therapy PH-RESPONSIVE Chemodynamic therapy Oxygen vacancy 

分 类 号：TB383[一般工业技术—材料科学与工程]