“冬病夏治法”对慢性阻塞性肺疾病作用的系统评价  

Systematic Review on Effects of “Treatment of Winter Diseases in Summer” for Chronic Obstructive Pulmonary Disease

作　　者：冯颖童 李丽 姜斯佳 王建新 胡宇洋 吴卓耘 高学敏 王景霞 FENG Yingtong;LI Li;JIANG Sijia;WANG Jianxin;HU Yuyang;WU Zhuoyun;GAOXuemin;WANG Jingxia(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Clinical Pharmacology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Project Management Center,Beijing Yaohai Ningkang Pharmaceutical Technology Co.,Ltd,Beijing 102206,China;Dept.of Orthopedics,the Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学中医学院,北京100029 [2]中国中医科学院西苑医院临床药理研究所,北京100091 [3]北京药海宁康医药科技有限公司项目管理中心,北京102206 [4]北京中医药大学第三附属医院骨科,北京100029

出　　处：《中国医院用药评价与分析》2024年第8期978-983,共6页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：北京中医药薪火传承“新3+3”工程建设单位王玉英三名传承工作室(No.2023-SZ-F-22);北京中医药大学高学敏教授名师坊(No.MSGZF-201809)。

摘　　要：目的:对“冬病夏治法”用于慢性阻塞性肺疾病(COPD)的临床疗效进行系统评价,以期为COPD的防治及冬病夏治的临床应用提供有价值的循证依据。方法:检索中国知网、万方数据库、维普数据库、PubMed、Web of Science、Embase(检索时间为建库至2023年8月),筛选较高质量的冬病夏治法用于COPD的临床随机对照试验研究(对照组采用常规疗法,如给予支气管舒张剂、吸入糖皮质激素、氧疗、戒烟等;研究组在对照组的基础上加用“冬病夏治法”或者单纯采用“冬病夏治法”),提取数据,应用RevMan 5.4.1软件进行Meta分析。结果:最终纳入65项随机对照试验研究,涉及5 736例受试者(研究组2 880例,对照组2 856例)。Meta分析结果表明,与常规疗法比较,“冬病夏治法”用于COPD的治疗可提高总有效率(OR=3.97,95%CI=3.32~4.74,P<0.000 01),提高第1秒用力呼气容积占用力肺活量百分比(MD=3.76,95%CI=2.66~4.85,P<0.000 01),降低圣乔治呼吸问卷评分(MD=-4.83,95%CI=-6.39~-3.27,P<0.000 01),差异均有统计学意义。结论:现有证据表明,对于COPD患者,在常规疗法的基础上加用中医“冬病夏治法”或单纯采用“冬病夏治法”,治疗效果更好。OBJECTIVE:To systematically review the clinical efficacy of“treatment of winter diseases in summer”for chronic obstructive pulmonary disease(COPD),so as to provide valuable evidence-based basis for the prevention and treatment of COPD and clinical application of“treatment of winter diseases in summer”.METHODS:CNKI,Wanfang Data,VIP,PubMed,Web of Science,and Embase databases were retrieved(the retrieval time was from the establishment of the database to Aug.2023)to collect the high-quality clinical randomized controlled trial of“treatment of winter diseases in summer”for COPD(the control group received conventional therapy,such as bronchodilator,inhaled glucocorticoid,oxygen therapy,and smoking cessation;the study group received“treatment of winter diseases in summer”on the basis of the control group or simply received“treatment of winter diseases in summer”).Data were extracted and Meta-analysis was performed by using RevMan 5.4.1 software.RESULTS:Totally 65 randomized controlled trials were enrolled,including 5736 patients(with 2880 cases in study group and 2856 cases in control group).Meta-analysis showed that compared with conventional therapy,“treatment of winter diseases in summer”could improve the total effective rate of COPD(OR=3.97,95%CI=3.32-4.74,P<0.00001),increase the percentage of forced expiratory volume in one second to forced vital capacity(MD=3.76,95%CI=2.66-4.85,P<0.00001),decrease the score of St George’s respiratory questionnaire(MD=-4.83,95%CI=-6.39--3.27,P<0.00001),the differences were statistically significant.CONCLUSIONS:Existing evidence suggests that for COPD patients,the treatment effect is better if the traditional Chinese medicine“treating winter disease in summer”or“treating winter disease in summer”is added on the basis of conventional therapy.

关 键 词：“冬病夏治法” 慢性阻塞性肺疾病 穴位敷贴 META分析 系统评价 

分 类 号：R932[医药卫生—生药学]