慢性阻塞性肺疾病患者血清MCP-4、TRPC6水平与肺功能及病情严重程度的关系  

Relationship between serum MCP-4,TRPC6 levels and lung function and severity of condition in patients with chronic obstructive pulmonary disease

作　　者：崔丽平 辛大永 李霞 CUI Liping;XIN Dayong;LI Xia(Department of Respiratory,Beijing Traditional Chinese Medicine Hospital Shunyi Hospital,Beijing 101300,China)

机构地区：[1]北京中医医院顺义医院呼吸科,北京101300

出　　处：《临床肺科杂志》2024年第9期1340-1344,共5页Journal of Clinical Pulmonary Medicine

基　　金：北京市属医院科研培育计划项目(No.PZ2018007)。

摘　　要：目的 探讨慢性阻塞性肺疾病(慢阻肺)患者血清单核细胞趋化蛋白4(MCP-4)、经典瞬时感受器电位通道蛋白-6(TRPC-6)水平与肺功能及病情严重程度的关系。方法 选取2020年6月至2023年6月期间109例慢阻肺患者作为慢阻肺组,同期选取109例健康体检者作为对照组。根据全球慢阻肺倡议(GOLD),按照1秒用力呼气容积(FEV_(1))占预计值的百分比(FEV_1%)进行严重程度分级,将慢阻肺患者划分为轻度组30例,中度组34例,重度组27例,极重度组18例。采用酶联免疫吸附法(ELISA)检测血清MCP-4、TRPC6的表达水平;Pearson法分析血清MCP-4、TRPC6和肺功能之间的相关性;多因素Logistic回归分析影响慢阻肺发生的因素。结果 与对照组相比,COPD组患者MCP-4、TRPC6表达水平均显著升高(P<0.05)。COPD组深吸气量(IC)、呼气峰值流速(PEF)、FEV_(1)%、1秒率(FEV_(1)/FVC)水平均低于对照组,残总比(RV/TLC)水平高于对照组,且差异有统计学意义(P<0.05)。与轻度组相比,中度、重度、极重度组COPD患者的MCP-4、TRPC6表达水平分别依次显著升高(P<0.05)。与轻度组相比,中度、重度、极重度组COPD患者IC、PEF、FEV_(1)%、FEV_(1)/FVC水平依次显著降低,RV/TLC水平依次显著升高(P<0.05)。根据Pearson相关性分析,COPD患者MCP-4、TRPC6表达水平均与RV/TLC存在正相关性(P<0.05),与IC、PEF、FEV_(1)%、FEV_(1)/FVC存在负相关性(P<0.05)。多因素Logistic回归分析发现,MCP-4、TRPC6、RV/TLC是影响COPD发生的危险因素(P<0.05),IC、PEF、FEV_(1)%、FEV_(1)/FVC是影响COPD发生的保护因素(P<0.05)。结论 COPD患者血清MCP-4、TRPC6表达水平显著升高,与肺功能及疾病严重程度密切相关。Objective To investigate the relationship between serum monocyte chemotactic protein-4(MCP-4)and classical transient receptor potential channel protein-6(TRPC6)levels and lung function and severity of chronic obstructive pulmonary disease(COPD).Methods From June 2020 to June 2023,109 COPD patients were collected as the COPD group,and 109 healthy individuals were collected as the control group.According to the Global COPD Initiative(GOLD),COPD patients were classified into a mild group of 30 cases,a moderate group of 34 cases,a severe group of 27 cases,and an extremely severe group of 18 cases based on the percentage of forced expiratory volume in one second(FEV_(1)%)to the expected value(FEV_(1)%).Enzyme-linked immunosorbent assay(ELISA)was applied to detect the expression levels of serum MCP-4 and TRPC6;Pearson method was applied to analyze the correlation between serum MCP-4,TRPC6,and lung function;multivariate Logistic regression was applied to analyze the factors that affected the occurrence of COPD.Results Compared with the control group,the expression levels of MCP-4 and TRPC6 in patients with COPD were greatly increased(P<0.05).The deep inspiratory volume(IC),peak expiratory flow rate(PEF),FEV_(1)%,and 1-second rate(FEV_(1)/FVC)in the COPD group were lower than those in the control group,while the residual to total ratio(RV/TLC)was higher than that in the control group(P<0.05).Compared with the mild group,the expression levels of MCP-4 and TRPC6 in moderate,severe,and extremely severe COPD patients were obviously increased in sequence(P<0.05).Compared with the mild group,IC,PEF,FEV_(1)%,and FEV_(1)/FVC in moderate,severe,and extremely severe COPD patients decreased obviously,while RV/TLC increased greatly(P<0.05).According to Pearson correlation analysis,the expression levels of MCP-4 and TRPC6 in COPD patients were positively correlated with RV/TLC(P<0.05),and negatively correlated with IC,PEF,FEV_(1)%,FEV_(1)/FVC(P<0.05).Multivariate Logistic regression analysis found that MCP-4,TRPC6,RV/TLC were risk fa

关 键 词：慢性阻塞性肺疾病 单核细胞趋化蛋白4 经典瞬时感受器电位通道蛋白-6 肺功能 病情 

分 类 号：R563.9[医药卫生—呼吸系统]