基于态靶医学探讨毒热理论以痈论治胃溃疡活动期  

Treatment of Gastric Ulcer in Active Stage with Carbuncle Theory in Toxicity-heat Theory Based on"State-target Medicine"

作　　者：陈力铭 刘国政 杨硕[2] 李言 孙阳阳 边玥凝 赵一霖 肖景东[3] CHEN Liming;LIU Guozheng;YANG Shuo;LI Yan;SUN Yangyang;BIAN Yuening;ZHAO Yilin;XIAO Jingdong(Liaoning University of Traditional Chinese Medicine(TCM),Shenyang 110847,China;Liaoning University of TCM Hospital Subsidiary Fourth,Shenyang 110101,China;First Affiliated Hospital of Liaoning University of TCM,Shenyang 110000,China)

机构地区：[1]辽宁中医药大学,沈阳110847 [2]辽宁中医药大学附属第四医院,沈阳110101 [3]辽宁中医药大学附属医院,沈阳110000

出　　处：《中国实验方剂学杂志》2024年第18期217-227,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82074296)。

摘　　要：“态靶医学”是仝小林院士基于现代医学发展现状提出的中医诊疗理论体系。胃溃疡活动期作为胃癌前状态,对人们的健康产生了巨大影响,国医大师周学文教授针对胃溃疡活动期创新性地提出“毒热”病因理论,对临床诊疗起到重要的指导作用。文章以“态靶医学”理论体系为框架对国医大师周学文教授基于“毒热”理论运用消痈溃得康治疗胃溃疡活动期的理、法、方、药进行再次阐发。确立胃溃疡“胃痈”之中医病名,认为胃溃疡因“毒”而生,以“毒热”为本,疾病过程中“毒”“热”“虚”“瘀”态并存,将其病机发展分为毒热蕴结期、毒热伤正期、正虚毒恋期3个阶段。周学文教授基于胃溃疡“内痈”的定位提出“以痈论治”胃溃疡活动期,将外科治法“消”“托”“补”引入胃溃疡活动期的治疗中,将“清热解毒、消痈生肌”作为疾病基本治法,对于不同阶段,又对清热解毒法、托腐生肌法、健脾和胃法的使用各有侧重,并创立出能够态靶同调胃溃疡活动期的“以痈论治”代表方剂消痈溃得康。"State-target medicine"is a traditional Chinese medicine(TCM)diagnosis and treatment theoretical system proposed by Academician Tong Xiaolin based on the current development of modern medicine.The active stage of gastric ulcer,as a precancerous state of gastric cancer,has a great impact on people's health.Prof.ZHOU Xuewen,a master of TCM,innovatively put forward the theory of"toxicity-heat"etiology for the active stage of gastric ulcer,which plays an important guiding role in clinical diagnosis and treatment.The article took the theoretical system of"state-target medicine"as the framework to explain the rationale,method,formula,and medicine of Prof.ZHOU Xuewen,who applied the Xiaoyong Kuidekang based on the"toxicity-heat"theory to treat the gastric ulcer in the active stage.The Chinese medical name of gastric ulcer,"gastric carbuncle",was established,and it was believed that gastric ulcer is born due to"toxicity"and is based on"toxicity and heat".In the course of the disease,"toxicity","heat","deficiency",and"stasis"coexisted,and its pathogenesis was divided into three phases,namely,toxicity-heat accumulation phase,toxicity-heat affecting the health phase,and weakened body resistance and strengthened toxicity phase.According to the positioning of gastric ulcer as an"internal carbuncle",Prof.ZHOU Xuewen proposed the treatment of gastric ulcer in the active stage with"carbuncle theory"and introduced the surgical methods of"elimination","support",and"tonifying"into the treatment of gastric ulcer in the active stage.Prof.ZHOU Xuewen took"clearing heat and removing toxins,eliminating carbuncle and generating muscle"as the basic treatment of the disease.For different stages of the disease,Prof.ZHOU Xuewen emphasized the use of the methods of clearing heat and removing toxins,supporting rot and muscle growth,and strengthening the spleen and harmonizing the stomach and created the representative formula for the treatment of gastric ulcer in the active stage with"carbuncle theory",namely"Xiaoyong Kuidekang",which could re

关 键 词：态靶医学 胃溃疡活动期 毒热理论 以痈论治 消痈溃得康 

分 类 号：R856.2[医药卫生—航空、航天与航海医学] R969.4[医药卫生—临床医学] R242R573R286R256.3