2010—2019年儿童食物不耐受特异性IgG抗体检测结果的大样本回顾性研究——以河北某医院为例  

A Large-Scale Retrospective Study on Food-specific IgG Antibodies for Food Intolerance in Children from Hebei Provincein 2010—2019

作　　者：朱绘霖 王蕾[1] 褚泽军 郑青松 吴晓蒙 GUO Shan-shan;PANG Jin-zhu;ZHANG Ying-chun(Inner Mongolia Mengniu Dairy(Group)Co.,Ltd.,Beijing 101107,China)

机构地区：[1]中国农业大学食品科学与营养工程学院,北京100083

出　　处：《中国食物与营养》2024年第8期67-73,66,共8页Food and Nutrition in China

基　　金：国家重点研发计划项目(项目编号:2023YFF1105203)。

摘　　要：目的:通过对河北地区儿童血清中14种食物不耐受特异性IgG的检测结果进行分析,为儿童饮食结构的科学指导与调整提供数据支撑。方法:2010—2019年期间,河北省某医院采用ELISA方法测定儿童患者血清中14种食物特异性IgG的水平,并按性别和年龄进行统计分析。共纳入31312例0~14岁的儿童病例。结果:儿童对鸡蛋的IgG阳性率最高(57.13%),对猪肉的IgG阳性率最低(1.95%),超过一半的儿童对两种或以上食物表现出不耐受。阳性率在不同年份有所波动,其中西红柿和小麦的变化趋势相似。不同性别和不同年龄组间的食物不耐受阳性率存在显著差异,女童的阳性率高于男童,婴幼儿组高于非婴幼儿组。结论:河北地区不同年龄和性别儿童血清中14种食物特异性IgG存在不同水平的检出,该结果对该地区儿童的个性化健康饮食规划和慢性疾病的预防具有参考价值。【Objective】To analyze the distribution characteristics of 14 food-specific IgG antibodies in children in Hebei province.【Method】From 2010 to 2019,ELISA was used to measure 14 food-specific IgG antibodies in children's serum in Hebei province and the data was analyzed thoroughly.A total of 31312 children aged 0 to 14 years were included in the study.【Result】The highest IgG positivity rate was found for eggs(57.13%)and the lowest for pork(1.95%)in the study cohort.Over half of the children analyzed showed intolerance to two or more types of food.The positivity rates of different food items fluctuated yearly,with similar trends for tomatoes and wheat.Intolerance varied significantly by gender and age.Females and younger children had higher intolerance rates.【Conclusion】Children in Hebei province showed various levels of 14 food-specific IgG antibodies based on age and gender,highlighting the need for personalized diet plans to prevent chronic diseases.

关 键 词：食物不耐受 儿童 IGG抗体 河北地区 影响因素 

分 类 号：R446.6[医药卫生—诊断学]