盐酸头孢吡肟中间体7-MPCA残留的测定方法  

An Method for Determination of Cefepime Hydrochloride Intermeidiate 7-MPCA Residua Content

作　　者：赵玉娟 魏宝军 贾金焕 张建丽 张文胜 杨梦德 Zhao Yujuan;Wei Baojun;Jia Jinhuan;Zhang Jianli;Zhang Wensheng;Yang Mengde(NCPC Hebei Pharmaceutical Co.,Ltd.,Shijiazhaung 052165,China;National and local joint engineering laboratory of antibiotic enzyme catalysis and crystallization technology,Shijiazhaung 052165,China;Hebei Province Cephalosporide Medicine Preparation Technology Innovation Center,Shijiazhaung 052165,China;NCPC Hebei Pharmaceutical Co.,Ltd.,Hebei Province Company Technology Centerr,Shijiazhaung 052165,China)

机构地区：[1]华北制药河北华民药业有限责任公司,河北石家庄052165 [2]抗生素酶催化与结晶技术国家地方联合工程实验室,河北石家庄052165 [3]河北省头孢类药物制备技术创新中心,河北石家庄052165 [4]华北制药河北华民药业有限责任公司河北省企业技术中心,河北石家庄052165

出　　处：《山东化工》2024年第14期172-175,共4页Shandong Chemical Industry

摘　　要：建立了用高效液相色谱仪测定反应液中关键中间体7-氨基-3-[(1-甲基四氢吡咯)甲基]-3-头孢-4-羧酸盐酸盐残留含量的分析方法,能够更好地控制盐酸头孢吡肟合成过程中的反应终点,及时进行下步工艺操作。经过验证,该方法具有较好的专属性、精密度和耐用性,操作简单,重复性好,可为盐酸头孢吡肟中间体7-MPCA残留检测提供试验依据。To establish an High-performance liquid chromatography method for the residual content determination of Cefepime Hydrochloride Intermeidiate(R,R)-7-amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate hychloride content in reaction fluid,the reaction end point of cefepime hydrochloride synthesis process can be better controlled,and the subsequent process operation can be carried out.This established method is simple,specific,Precision,durability and good repeatability,which can be used to determine the residual content of 7-MPCA in the reaction fluid.

关 键 词：高效液相色谱法 盐酸头孢吡肟 7-MPCA 残留含量 

分 类 号：TQ460[化学工程—制药化工]