一种高效可操作的经颅电刺激电极优化方法  

An efficient and practical electrode optimization method for transcranial electrical stimulation

作　　者：谢旭 王敏敏[1,2] 张韶岷 XIE Xu;WANG Minmin;ZHANG Shaomin(College of Biomedical Engineering&Instrument science,Zhejiang University,Hangzhou 310027,P.R.China;Key Laboratory for Biomedical Engineering of Ministry of Education,Qiushi Academy for Advanced Studies,Zhejiang University,Hangzhou 310027,P.R.China)

机构地区：[1]浙江大学生物医学工程与仪器科学学院,杭州310027 [2]浙江大学求是高等研究院浙江大学生物医学工程教育部重点实验室,杭州310027

出　　处：《生物医学工程学杂志》2024年第4期724-731,741,共9页Journal of Biomedical Engineering

基　　金：科技创新2030-重大项目(2021ZD0200401);浙江省重点研发计划(2021C03107);浙江省“尖兵”“领雁”研发攻关计划(2023C03026,2023C03081)。

摘　　要：经颅电刺激是一种极具潜力的无创神经调控技术。基于个体经颅电刺激电场仿真模型的电极优化方法可依据个体头部组织结构差异给出个性化电刺激参数,显著提升经颅电刺激的干预靶向性。然而,目前所提出的电极优化方法存在计算耗时较长(通常大于1 d)、未考虑刺激器输出通道数受限等局限,进一步阻碍了电极优化方法在临床中的应用。因此,本文提出了一种高效可操作的电极优化方法,可以结合目标脑区强度和聚焦性两个目标进行优化并约束所使用的电极数量,且计算快速。与目前常用的电极优化方法相比,本文所提方法可以在保证优化效果的基础上,极大地节省计算时间(耗时减小85.9%),并且可依据刺激器实际输出通道数设置优化的电极使用个数,将电流分散到多个电极,提升经颅电刺激的使用耐受性。本文提出的电极优化方法具有高效率和易操作的特点,可为个体精准经颅电刺激的实施提供一定的数据支撑和参考。Transcranial electrical stimulation(TES)is a non-invasive neuromodulation technique with great potential.Electrode optimization methods based on simulation models of individual TES field could provide personalized stimulation parameters according to individual variations in head tissue structure,significantly enhancing the stimulation accuracy of TES.However,the existing electrode optimization methods suffer from prolonged computation times(typically exceeding 1 d)and limitations such as disregarding the restricted number of output channels from the stimulator,further impeding their clinical applicability.Hence,this paper proposes an efficient and practical electrode optimization method.The proposed method simultaneously optimizes both the intensity and focality of TES within the target brain area while constraining the number of electrodes used,and it achieves faster computational speed.Compared to commonly used electrode optimization methods,the proposed method significantly reduces computation time by 85.9%while maintaining optimization effectiveness.Moreover,our method considered the number of available channels for the stimulator to distribute the current across multiple electrodes,further improving the tolerability of TES.The electrode optimization method proposed in this paper has the characteristics of high efficiency and easy operation,potentially providing valuable supporting data and references for the implementation of individualized TES.

关 键 词：经颅电刺激 电极优化 高效计算 有限元 

分 类 号：R318[医药卫生—生物医学工程]