人工肝中空纤维膜组件内胆红素与牛血清白蛋白传质行为研究  

Mass transfer of bilirubin and bovine serum albumin in hollow fiber membrane module of artificial liver

作　　者：王子恒 许少锋 余一帆 陆俊杰 张学昌 WANG Ziheng;XU Shaofeng;YU Yifan;LU JunJie;ZHANG Xuechang(School of Mechatronics and Energy Engineering,NingboTech University,Ningbo,Zhejiang 315100,P.R.China;School of Mechanical Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,P.R.China;School of Mechanical Engineering,Zhejiang University,Hangzhou 310027,P.R.China)

机构地区：[1]浙大宁波理工学院机电与能源工程学院,浙江宁波315100 [2]浙江理工大学机械工程学院,杭州310018 [3]浙江大学机械工程学院,杭州310027

出　　处：《生物医学工程学杂志》2024年第4期742-750,共9页Journal of Biomedical Engineering

基　　金：浙江省自然科学基金重点项目(LZ21A020001);国家自然科学基金项目(51605432);宁波市科技重大专项项目(2024QL023,2023Z022)。

摘　　要：了解人工肝中空纤维膜组件传质行为对其高效解毒具有重要指导意义。建立了中空纤维膜组件内流动传质的三维数值模拟模型,研究了小分子胆红素与大分子牛血清白蛋白(BSA)在组件内的传质行为,讨论了管程流量、壳程流量、中空纤维管长度对胆红素与BSA传质的影响。研究结果表明小分子胆红素的传质方式是对流传质和扩散传质二者兼具,而大分子BSA的传质方式以对流传质为主;胆红素和BSA的清除速率随着管程流量增大而提升,也随着中空纤维管长度增加而提升;随着壳程流量增大,胆红素的清除速率先快速提升再缓慢上升达到渐近值,而BSA的清除速率随壳程流量增大而逐渐减小。研究成果可以为人工肝中空纤维膜组件的结构优化设计和临床操作参数提供依据。Understanding the mass transfer behaviors in hollow fiber membrane module of artificial liver is important for improving toxin removal efficiency.A three-dimensional numerical model was established to study the mass transfer of small molecule bilirubin and macromolecule bovine serum albumin(BSA)in the hollow fiber membrane module.Effects of tube-side flow rate,shell-side flow rate,and hollow fiber length on the mass transfer of bilirubin and BSA were discussed.The simulation results showed that the clearance of bilirubin was significantly affected by both convective and diffusive solute transport,while the clearance of macromolecule BSA was dominated by convective solute transport.The clearance rates of bilirubin and BSA increasd with the increase of tube-side flow rate and hollow fiber length.With the increase of shell-side flow rate,the clearance rate of bilirubin first rose rapidly,then slowly rose to an asymptotic value,while the clearance rate of BSA gradually decreased.The results can provide help for designing structures of hollow fiber membrane module and operation parameters of clinical treatment.

关 键 词：人工肝 中空纤维膜组件 胆红素 牛血清白蛋白 传质行为 

分 类 号：R318.14[医药卫生—生物医学工程]