静电纺聚氨酯纤维在组织工程领域中的研究进展  

Research progress of electrospinning polyurethane fiber in the field of biomedical tissue engineering

作　　者：焦恩祥 孙子茹 胥美虹 吴则 刘元标 郭恺 任桂莹 张海军(综述) 刘百超(审校) JIAO Enxiang;SUN Ziru;XU Meihong;WU Ze;LIU Yuanbiao;GUO Kai;REN Guiying;ZHANG Haijun;LIU Baichao(College of Materials Science and Engineering,Shandong University of Technology,Zibo,Shandong 255000,P.R.China;National Local Joint Engineering Laboratory of Biomedical Material Modification Technology,Dezhou,Shandong 253000,P.R.China;School of Medicine,Tongji University,Shanghai 200000,P.R.China;Department of Interventional Medicine,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,P.R.China)

机构地区：[1]山东理工大学材料科学与工程学院,山东淄博255000 [2]生物医用材料改性技术国家地方联合工程实验室,山东德州253000 [3]同济大学医学院,上海200000 [4]青岛大学附属医院介入医学科,山东青岛266000

出　　处：《生物医学工程学杂志》2024年第4期840-847,共8页Journal of Biomedical Engineering

基　　金：山东省重点研发计划(重大科技创新工程)(2019JZZY011108)。

摘　　要：聚氨酯材料具有良好的生物相容性、血液相容性、力学性能、耐疲劳性和可加工性,一直以来都是备受关注的生物医用材料。利用静电纺丝技术制备的聚氨酯纤维能够较好地模拟天然细胞外基质(ECMs)结构,种子细胞可较好地黏附和增殖,满足组织修复和重建的要求。本综述旨在通过介绍静电纺聚氨酯纤维在骨组织工程、皮肤组织工程、神经组织工程、血管组织工程和心脏组织工程方面的研究进展,帮助研究人员深入了解静电纺聚氨酯纤维在组织工程和再生医学中的实际应用。Polyurethane materials have good biocompatibility,blood compatibility,mechanical properties,fatigue resistance and processability,and have always been highly valued as medical materials.Polyurethane fibers prepared by electrostatic spinning technology can better mimic the structure of natural extracellular matrices(ECMs),and seed cells can adhere and proliferate better to meet the requirements of tissue repair and reconstruction.The purpose of this review is to present the research progress of electrostatically spun polyurethane fibers in bone tissue engineering,skin tissue engineering,neural tissue engineering,vascular tissue engineering and cardiac tissue engineering,so that researchers can understand the practical applications of electrostatically spun polyurethane fibers in tissue engineering and regenerative medicine.

关 键 词：静电纺丝 聚氨酯纤维 组织工程 细胞外基质 

分 类 号：R318.08[医药卫生—生物医学工程]