抗溶胀水凝胶在生物医学领域的研究进展  

Research progress on anti-swelling hydrogels in biomedical field

作　　者：宋昌隆 付翔 唐璐(综述)[2] 董志红(审校) SONG Changlong;FU Xiang;TANG Lu;DONG Zhihong(School of Mechanical Engineering,Chengdu University,Chengdu 610106,P.R.China;Affiliated Hospital and Clinical College,Chengdu University,Chengdu 610031,P.R.China)

机构地区：[1]成都大学机械工程学院,成都610106 [2]成都大学附属医院,成都610031

出　　处：《生物医学工程学杂志》2024年第4期848-853,共6页Journal of Biomedical Engineering

基　　金：四川省科技厅科技成果转化示范项目(2023ZHCG0051);省级大学生创新创业训练计划创业实践与创业训练项目(S202311079008X);四川省教育厅高等教育人才培养质量和教学改革项目(JG2021-1111);成都大学CC国家众创空间创新创业教育专项项目(ccyg202301003)。

摘　　要：水凝胶是一种可降解亲水聚合物,但亲水性过大导致体积变大、弹性模量降低以及结构松散,影响其使用;尤其是在生物医学工程领域,水凝胶的过分溶胀会压迫神经,且降解速率过快,导致释放的离子与组织生长不匹配等问题。因此,抗溶胀的水凝胶是近年来的研究热点,本文综述了抗溶胀水凝胶的近期研究进展,从水凝胶的溶胀机制和制备方法出发,详细阐述其在生物医学工程领域的应用发展,以期为抗溶胀水凝胶领域的研究者提供一些参考与借鉴。Hydrogel is a kind of degradable hydrophilic polymer,but excessive hydrophilicity leads to larger volume,lower elastic modulus and looser structure,which further affect its use.Especially in the field of biomedical engineering,excessive swelling of the hydrogel can compress the nerves and improve degradation rate resulting in mismatch of tissue growth and released ions.Therefore,anti-swelling hydrogel has been a research hotspot in recent years.This paper reviews the recent research progress on anti-swelling hydrogel,and expounds the application mechanism and preparation method of hydrogel in biomedical engineering,aiming to provide some references for researchers in the field of anti-swelling hydrogel.

关 键 词：水凝胶 亲水性 抗溶胀 生物医学 

分 类 号：R318.08[医药卫生—生物医学工程]