眼内液细胞因子检测在糖尿病黄斑水肿中临床意义的研究进展  

Research progress of clinical importance of detecting cytokines in the intraocular fluid in diabetic macular edema

作　　者：曾国强 钟键波 张怡 叶佰康 窦晓燕[3] 蔡莉 Zeng Guoqiang;Zhong Jianbo;Zhang Yi;Ye Baikang;Dou Xiaoyan;Cai Li(Department of Ophthalmology,Shenzhen University General Hospital,Shenzhen 518000,China;Shenzhen University Health Science Center,Shenzhen 518000,China;Department of Ophthalmology,Shenzhen Second People's Hospital,The First Affiliated Hospital of Shenzhen University,Shenzhen 518000,China)

机构地区：[1]深圳大学总医院眼科,深圳518000 [2]深圳大学医学部,深圳518000 [3]深圳大学第一附属医院深圳市第二人民医院眼科,深圳518000

出　　处：《中华眼底病杂志》2024年第8期651-655,共5页Chinese Journal of Ocular Fundus Diseases

基　　金：深圳市科创委国际科技合作项目(GJHZ20200731095005016);深圳大学医工交叉研究基金(00000326);深圳市科创委基础研究重点项目(JCYJ20200109115627045)。

摘　　要：糖尿病黄斑水肿(DME)是导致糖尿病患者视力丧失的最主要原因,其发病机制复杂,临床治疗效果欠佳。DME对视力危害极大,随着相关研究的深入其相关病理机制也越来越明确,治疗方式也发生了相应的变化。近年来眼内液细胞因子检测技术快速发展,对DME的机制提供了更加合理的阐释以及使治疗方案的选择更加合理化。但眼内液的获取为有创操作,存在一定的感染风险,若能将眼内液中相关的细胞因子水平与其相关的影像学指标结合起来,则能为DME的治疗和预后监测提供更好的选择,减少有创操作风险,未来还需要进一步的临床研究去探索其相关性。Diabetic macular edema(DME)is the main cause of vision loss in diabetic patients,its pathogenesis is complicated,and the clinical treatment is not good.DME is extremely harmful to vision.With the deepening of relevant studies,its related pathological mechanism has become more and more clear,and the treatment methods have also changed accordingly.In recent years,the rapid development of intracocular fluid cytokine detection technology has provided a more reasonable explanation of the mechanism of DME and made the choice of treatment more reasonable.However,the acquisition of intraocular fluid is an invasive operation with a certain risk of infection.If the level of relevant cytokines in intraocular fluid can be linked with the relevant imaging indicators,it will provide a better choice for the treatment and prognosis monitoring of DME and reduce the risk of invasive operation,and further clinical studies are needed to explore its correlation in the future.

关 键 词：眼内液 细胞因子 黄斑水肿 糖尿病视网膜病变 综述 

分 类 号：R587.2[医药卫生—内分泌] R774.5[医药卫生—内科学]