辅助生殖技术子代出生体质量的影响因素及相关机制研究进展  

Research progress on influencing factors and related mechanisms of birth weight in offspring of assisted reproductive technology

作　　者：焦洁静 耿晨 张轶媛 崔琳琳[1] Jiao Jiejing;Geng Chen;Zhang Yiyuan;Cui Linlin(Center for Reproductive Medicine,the Second Hospital,Cheeloo College of Medicine,Shandong University,Research Unit of Gametogenesis and Health of ART-Ofspring,Chinese Academy of Medical Science(2021RU001),Key Laboratory of Reproductive Endocrinology of Ministry of Education,Shandong University,Shandong Key Laboratory of Reproductive,Shandong Provincial Clinical Research Center for Reproductive Health,Shandong Technology Innovation Center for Reproductive Health,National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学生殖医学研究中心(山东大学第二医院)、中国医学科学院配子发生与辅助生殖子代健康研究创新单元(2021RU001)、生殖内分泌教育部重点实验室(山东大学)、山东省生殖医学重点实验室、山东省生殖健康临床医学研究中心、山东省生殖健康技术创新中心、国家辅助生殖与优生工程技术研究中心,济南250012

出　　处：《中华生殖与避孕杂志》2024年第7期742-749,共8页Chinese Journal of Reproduction and Contraception

摘　　要：随着不孕症发病率的升高,辅助生殖技术(assisted reproductive technology,ART)逐渐成为不孕人群的主要甚至唯一治疗方法。大量证据表明,ART子代围产期结局与自然受孕子代间存在差异,如ART子代低出生体质量风险增加、远期代谢异常风险增加等。然而,这种差异往往不是ART单一作用的结局,不孕症以及胎儿自身因素也发挥了一定的作用。由于出生体质量对新生儿远期健康具有重要作用,现就ART中可能影响子代出生体质量的因素及相关机制进行综述,从而为改善ART子代健康结局提供一定的参考价值。With the increase of the incidence rate of infertility,assisted reproductive technology(ART)has gradually become the main or even the only treatment for infertile people.A large amount of evidence showed that perinatal outcomes of ART offspring are different from those of naturally conceived offspring,such as the increased risk of low birth weight and long-term metabolic abnormalities.However,beside of ART,infertility and the fetus factor also play a role in the poor pregnancy outcome.Since birth weight plays an important role in the long-term health of newborns,this article reviewed the factors and related mechanisms that may affect the birth weight of offspring conceived by ART,so as to contribute improving the pregnancy outcome.

关 键 词：生殖技术 辅助 出生体质量 妊娠结局 多囊卵巢综合征 不孕症 

分 类 号：R714.8[医药卫生—妇产科学]