生殖道衣原体和淋球菌感染在不孕不育人群中的分析  

Analysis of genital chlamydia and gonococcal infections in infertility

作　　者：李翔[1] 王陆颖[1] 李颖佳[2] Li Xiang;Wang Luying;Li Yingjia(Department of Gynecology,The Third Xiangya Hospital of Central South University,Changsha 410013,China;Clinical Laboratory,The Third Xiangya Hospital of Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院妇科,长沙410013 [2]中南大学湘雅三医院检验科,长沙410013

出　　处：《中华预防医学杂志》2024年第8期1236-1241,共6页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金(31800774)。

摘　　要：本研究分析衣原体(CT)和淋球菌(NG)在女性不孕和男性不育人群中的感染情况,探讨CT和NG感染与不孕不育的相关性。采取病例对照研究回顾性分析2021年1月至2022年12月中南大学湘雅三医院患者送检标本的CT和NG结果,初诊为不孕或不育的划分为不孕不育组,同期就诊的近3年内有孕育史的患者系统随机抽样设为对照组,对不同亚组内的CT和NG感染率进行χ^(2)分析。结果显示,总共采集标本32184份,CT感染率为4.41%(1419/32184),NG感染率为1.42%(457/32184)。在全部标本中,选择将女性首次临床诊断为不孕、男性首次诊断为不育者,划分为不孕不育组(n=3366),其中女性标本为2987例,男性标本为379例;在全部标本中,选择同期接受门诊检查的近3年内有孕育史人群系统随机抽样纳入对照组(n=3366),其中女性标本为2509例,男性标本为857例。其中不孕不育组的CT感染率13.63%(458/3366)明显高于对照组3.30%(111/3366),差异有统计学意义(χ^(2)=4.245,P<0.05),NG感染率6.38%(214/3366)明显高于对照组0.89%(30/3366),差异有统计学意义(χ^(2)=4.011,P<0.05)。女性生殖道拭子标本共23992份,其中不孕组有2987份,对照组有2509份,不孕组的CT感染率10.41%(311/2987)明显高于对照组3.75%(94/2509),差异有统计学意义(χ^(2)=4.132,P<0.05),NG感染率8.73%(261/2987)明显高于对照组0.40%(10/2509),差异有统计学意义(χ^(2)=4.242,P<0.05)。男性尿液标本共8192份,其中不育组有379份,对照组有857份,不育组的CT感染率13.72%(52/379)明显高于对照组3.38%(29/857),差异有统计学意义(χ^(2)=5.267,P<0.05),NG感染率12.60%(48/379)明显高于对照组0.93%(8/857),差异有统计学意义(χ^(2)=4.166,P<0.05)。不孕不育组的女性标本2987例中,原发不孕亚组有1034例,继发不孕亚组有1953例,两个亚组中CT感染率分别为7.93%(82/1034)和15.72%(307/1953),NG感染率分别为3.87%(40/1034)和8.65%(169/1953),比较差异无统计学意义(χ^(2)=0.185,PTo analyze the infection of chlamydia(CT)and gonorrhea(NG)in female infertility and male infertility population,and to explore the correlation between CT and NG infection and infertility.A case-control study was conducted to retrospectively analyze the specimens submitted by patients from the Third Xiangya Hospital of Central South University from January 2021 to December 2022.The results showed that a total of 32184 specimens were collected,and the positive rates of CT were 4.41%(1419/32184),and positive rats of NG were 1.42%(457/32184).In the infertility group(n=3366),2987 were females and 379 were males.In the control group(n=3366),2509 were females and 857 were males.The CT positive rate of the infertility group was 13.61%(458/3366),which was significantly higher than that of the control group 3.30%(111/3366),and the difference was statistically significant(χ^(2)=4.245,P<0.05),and the NG positive rate of the infertility group was 6.36%(214/3366),which was significantly higher than that of the control group 0.89%(30/3366),and the difference was statistically significant(χ^(2)=4.011,P<0.05).A total of 23992 female genital tract swab specimens were collected,including 2987 in the infertility group and 2509 in the control group,and the positive rate of CT in the female infertility subgroup was 10.41%(311/2987),which was significantly higher than that in the control group 3.75%(94/2509),the difference was statistically significant(χ^(2)=4.132,P<0.05),and the NG positive rate of 8.73%(261/2987)in the female infertility subgroup was significantly higher than that in the control group 0.40%(10/2509),and the difference was statistically significant(χ^(2)=4.242,P<0.05).A total of 8192 male urine samples were collected,including 379 in the infertility group and 857 in the control group,and the CT positive rate of the male infertility subgroup was 13.72%(52/379),which was significantly higher than that of the control group 3.38%(29/857),and the difference was statistically significant(χ^(2)=5.267,P<0.05),and the pos

关 键 词：衣原体 淋球菌 不孕不育症 

分 类 号：R711.6[医药卫生—妇产科学] R759.2[医药卫生—临床医学]