半夏白术天麻汤合桃红四物汤对原发性高血压痰瘀阻滞型患者血压昼夜节律的影响  

Influence of Banxia Baizhu Tianma Decoction and Taohong Siwu Decoction on Blood Pressure Circadian Rhythm in Patients with Essential Hypertension with Phlegm-stasis Block

作　　者：王婷 柏鲁宁 王云英 WANG Ting;BO Lu-Ning;WANG Yun-Ying(Department of Cardiology,the Third Hospital of Baoji,Baoji 721200,China;Department of Clinical Medicine,ShaanxiUniversity of Chinese Medicine,Baoji 712046,China;Department of Internal Medicine,Baoji Maternal and Child HealthHospital,Baoji 721099,China)

机构地区：[1]宝鸡市第三医院心血管二科,陕西宝鸡721200 [2]陕西中医药大学临床医学系,陕西宝鸡712046 [3]宝鸡市妇幼保健院内科,陕西宝鸡721099

出　　处：《中国药物经济学》2024年第7期73-77,共5页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨半夏白术天麻汤合桃红四物汤对原发性高血压痰瘀阻滞型患者血压昼夜节律的影响。方法 选取2021年1月至2022年1月于宝鸡市第三医院确诊为原发性高血压且符合痰瘀阻滞型的患者86例为研究对象,采用随机数字表法分为观察组和对照组,各43例,其中观察组因出现严重不良反应脱落1例。对照组予以苯磺酸氨氯地平片、缬沙坦氨氯地平片治疗,观察组在对照组基础上加用半夏白术天麻汤合桃红四物汤。比较两组患者治疗前后血压昼夜节律、血压变异性(BPV)[24 h平均收缩压变异性(24 h SBPV)、24 h平均舒张压变异性(24 h SBPV)]、晨峰血压(MBPS)、晨峰现象+发生率、中医证候积分以及中医证候疗效和不良反应发生情况。结果 治疗后,两组收缩压昼夜节律、舒张压昼夜节律显著改善,且观察组显著优于对照组,差异有统计学意义(P<0.05);治疗后两组24 h SBPV、24 h DBPV低于治疗前(P<0.05),且观察组低于对照组(P<0.05);治疗后两组MBPS、晨峰现象+发生率低于治疗前(P<0.05),且观察组MBPS、晨峰现象+发生率低于对照组(P<0.05);治疗后,两组中医证候积分显著降低(P<0.05),且观察组显著低于对照组(P<0.05);观察组中医证候疗效显著高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 半夏白术天麻汤合桃红四物汤可有效改善痰瘀阻滞型原发性高血压患者的血压昼夜节律,降低BPV,控制MBPS,改善中医证候积分,提高中医证候疗效,且不良反应较小,安全性高。Objective To explore the effect of Banxia Baizhu Tianma Tang combined with Taohong Siwu Tang on the circadian rhythm of blood pressure in patients with primary hypertension with phlegm stasis obstruction type.Methods A total of 86patients diagnosed with essential hypertension and consistent with phlegm stasis block type in Baoji Third Hospital from January 2021 to January 2022 were selected as the study objects,and were divided into observation group and control group by random number table method,with 43 cases in each group,of which 1 case fell out due to serious adverse reactions in the observation group.The control group was treated with amlodipine besylate tablets and valsartan amlodipine tablets,and the observation group was treated with Banxia Baizhu Tianma Decoction and Taohong Siwu decoction on the basis of the control group.Blood pressure circadian rhythm,blood pressure variability(BPV) [24 h mean systolic blood pressure variability(24 h SBPV),24 h mean diastolic blood pressure variability(24 h SBPV)],morning peak blood pressure(MBPS),morning peak phenomenon + incidence,TCM syndrome score before and after treatment,TCM syndrome efficacy and occurrence of adverse reactions were compared between the two groups.Results After treatment,the circadian rhythm of systolic blood pressure and diastolic blood pressure were significantly improved in both groups,and the observation group was significantly better than the control group,the difference was statistically significant(P<0.05).After treatment,24 h SBPV and 24 h DBPV in both groups were lower than before treatment(P<0.05),and observation group was lower than control group(P<0.05).After treatment,the incidence of MBPS and morning peak phenomenon + in the two groups was lower than before treatment(P<0.05),and the incidence of MBPS and morning peak phenomenon + in the observation group was lower than that in the control group(P<0.05).After treatment,the TCM syndrome score of both groups was significantly decreased(P<0.05),and the observation group was significa

关 键 词：半夏白术天麻汤 桃红四物汤 原发性高血压 痰瘀阻滞型 血压昼夜节律 血压变异性 晨峰血压 

分 类 号：R544.1[医药卫生—心血管疾病] R289.5[医药卫生—内科学]