Self‑Healing Dynamic Hydrogel Microparticles with Structural Color for Wound Management  

作　　者：Li Wang Xiaoya Ding Lu Fan Anne M.Filppula Qinyu Li Hongbo Zhang Yuanjin Zhao Luoran Shang 

机构地区：[1]Department of General Surgery,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,People’s Republic of China [2]Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,People’s Republic of China [3]Pharmaceutical Sciences Laboratory,Åbo Akademi University,20520 Turku,Finland [4]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,People’s Republic of China [5]Shanghai Xuhui Central Hospital,Zhongshan‑Xuhui Hospital,and the Shanghai Key Laboratory of Medical Epigenetics,the International Co‑laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology),Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,People’s Republic of China

出　　处：《Nano-Micro Letters》2024年第11期177-190,共14页纳微快报（英文版）

基　　金：supported by the Ruijin Hospital Guangci Introducing Talent Project;financial support from National Natural Science Foundation of China(82372145);the Research Fellow(Grant No.353146);Research Project(347897);Solutions for Health Profile(336355);InFLAMES Flagship(337531)grants from Academy of Finland;the Finland China Food and Health International Pilot Project funded by the Finnish Ministry of Education and Culture.

摘　　要：Chronic diabetic wounds confront a significant medical challenge because of increasing prevalence and difficult-healing circumstances.It is vital to develop multifunctional hydrogel dressings,with well-designed morphology and structure to enhance flexibility and effectiveness in wound management.To achieve these,we propose a self-healing hydrogel dressing based on structural color microspheres for wound management.The microsphere comprised a photothermal-responsive inverse opal framework,which was constructed by hyaluronic acid methacryloyl,silk fibroin methacryloyl and black phosphorus quantum dots(BPQDs),and was further re-filled with a dynamic hydrogel.The dynamic hydrogel filler was formed by Knoevenagel condensation reaction between cyanoacetate and benzaldehyde-functionalized dextran(DEX-CA and DEX-BA).Notably,the composite microspheres can be applied arbitrarily,and they can adhere together upon near-infrared irradiation by leveraging the BPQDs-mediated photothermal effect and the thermoreversible stiffness change of dynamic hydrogel.Additionally,eumenitin and vascular endothelial growth factor were co-loaded in the microspheres and their release behavior can be regulated by the same mechanism.Moreover,effective monitoring of the drug release process can be achieved through visual color variations.The microsphere system has demonstrated desired capabilities of controllable drug release and efficient wound management.These characteristics suggest broad prospects for the proposed composite microspheres in clinical applications.

关 键 词：Black phosphorus Structural color Dynamic hydrogel Inverse opal Wound management 

分 类 号：TQ427.26[化学工程] R318.08[医药卫生—生物医学工程]