Nanomaterial‑Based Repurposing of Macrophage Metabolism and Its Applications  

作　　者：Tingting Meng Danfeng He Zhuolei Han Rong Shi Yuhan Wang Bibo Ren Cheng Zhang Zhengwei Mao Gaoxing Luo Jun Den 

机构地区：[1]Institute of Burn Research,Southwest Hospital,State Key Laboratory of Trauma and Chemical Poisoning,Army Medical University,Chongqing 400038,People’s Republic of China [2]Department of Breast Surgery,Gansu Provincial Hospital,Lanzhou,Gansu 730030,People’s Republic of China [3]MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,People’s Republic of China

出　　处：《Nano-Micro Letters》2024年第11期494-528,共35页纳微快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.92168106 and 82222039).

摘　　要：Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease symptoms.Nanomaterials(NMs)have been engineered to monitor macrophage metabolism,enabling the evaluation of disease progression and the replication of intricate physiological signal patterns.They achieve this either directly or by delivering regulatory signals,thereby mapping phenotype to effector functions through metabolic repurposing to customize macrophage fate for therapy.However,a comprehensive summary regarding NM-mediated macrophage visualization and coordinated metabolic rewiring to maintain phenotypic equilibrium is currently lacking.This review aims to address this gap by outlining recent advancements in NM-based metabolic immunotherapy.We initially explore the relationship between metabolism,polarization,and disease,before delving into recent NM innovations that visualize macrophage activity to elucidate disease onset and fine-tune its fate through metabolic remodeling for macrophage-centered immunotherapy.Finally,we discuss the prospects and challenges of NM-mediated metabolic immunotherapy,aiming to accelerate clinical translation.We anticipate that this review will serve as a valuable reference for researchers seeking to leverage novel metabolic intervention-matched immunomodulators in macrophages or other fields of immune engineering.

关 键 词：Immunomodulatory nanomaterial Macrophage polarization Macrophage metabolic reprogramming Immune engineering 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]