急性胆囊炎患者胆囊切除术后血清CCK-8、TREM1水平与发生感染的关系  

Relationship between serum CCK-8 and TREM1 levels and infection in patients with acute cholecystitis after cholecystectomy

作　　者：陈立坤[1] 董彩丽 顾春芳[3] 杨淑红 尹玉杰 朱小静[4] 渠兴甫 CHEN Likun;DONG Caili;GU Chunfang;YANG Shuhong;YIN Yujie;ZHU Xiaojing;QU Xingfu(The Fourth Department of Surgery,Hebei Seventh People's Hospital,Baoding,Hebei 073000,China;Department of Clinical Laboratory,Hebei Seventh People's Hospital,Baoding,Hebei 073000,China;Department of Pharmacy,Hebei Seventh People's Hospital,Baoding,Hebei 073000,China;Department of Traditional Chinese Medicine,Hebei Seventh People's Hospital,Baoding,Hebei 073000,China)

机构地区：[1]河北省第七人民医院外四科,河北保定073000 [2]河北省第七人民医院检验科,河北保定073000 [3]河北省第七人民医院药剂科,河北保定073000 [4]河北省第七人民医院中医科,河北保定073000

出　　处：《检验医学与临床》2024年第17期2476-2479,2485,共5页Laboratory Medicine and Clinic

基　　金：河北省2020年度医学科学研究课题项目(20200620)。

摘　　要：目的分析急性胆囊炎(AC)患者胆囊切除术后血清胆囊收缩素-8(CCK-8)、髓系细胞触发受体1(TREM1)水平与发生感染的关系。方法将该院2020年12月至2022年12月收治的70例胆囊切除术后发生感染的AC患者纳入研究组,66例胆囊切除术后未发生感染的AC患者纳入对照组。采用酶联免疫吸附试验检测血清CCK-8、TREM1水平。采用Pearson相关分析胆囊切除术后发生感染AC患者血清中CCK-8、TREM1水平与炎症因子水平的相关性。采用受试者工作特征(ROC)曲线分析血清CCK-8、TREM1水平对AC患者胆囊切除术后发生感染的诊断价值。采用多因素Logistic回归分析AC患者胆囊切除术后感染的影响因素。结果研究组与对照组有胆囊结石、胆囊周边积液比例比较,差异均有统计学意义(P<0.05)。与对照组比较,研究组血清CCK-8水平明显降低,TREM1水平明显升高,差异均有统计学意义(P<0.05)。研究组C反应蛋白(CRP)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平明显高于对照组,差异均有统计学意义(P<0.05)。胆囊切除术后发生感染的AC患者血清CCK-8水平与CRP、IL-8、TNF-α水平均呈负相关(P<0.05),TREM1水平与CRP、IL-8、TNF-α水平均呈正相关(P<0.05)。ROC曲线分析显示,血清CCK-8与TREM1联合检测诊断AC患者胆囊切除术后发生感染的曲线下面积(AUC)明显大于CCK-8、TREM1单独检测的AUC(Z=5.703,P<0.001;Z=4.584,P<0.001)。有胆囊结石、胆囊周边积液及血清CCK-8水平降低、血清TREM1水平升高均为AC患者胆囊切除术后发生感染的危险因素(P<0.05)。结论胆囊切除术后发生感染的AC患者血清CCK-8水平降低,TREM1水平升高,二者联合检测能够提高对AC患者胆囊切除术后发生感染的诊断价值。Objective To analyze the relationship between serum cholecystokinin-8(CCK-8),triggering receptor expressed on myeloid cells 1(TREM1)levels and infection in patients with acute cholecystitis(AC)after cholecystectomy.Methods A total of 70 AC patients with infection after cholecystectomy in Hebei Seventh People's Hospital from December 2020 to December 2022 were selected as the study group,and 66 AC patients without infection after cholecystectomy were selected as the control group.Serum CCK-8 and TREM1 levels were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was used to analyze the correlation between serum CCK-8,TREM1 levels and inflammatory factors levels.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum CCK-8 and TREM1 levels for the occurrence of infection after cholecystectomy in AC patients.Multivariate Logistic regression was used to analyze the influencing factors of infection after cholecystectomy in AC patients.Results There were significant differences on team gallstones,gallbladder surrounding fluid proportion between the control group and the study group(P<0.05).Compared with the control group,the study group showed a significant decrease in serum CCK-8 level and a significant increase in TREM1 level,with statistically significant differences(P<0.05).The levels of C-reactive protein(CRP),interleukin-8(IL-8),tumor necrosis-α(TNF-α)in the study group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The serum CCK-8 level in patients with infection after cholecystectomy correlated negatively with CRP,IL-8,and TNF-α levels(P<0.05),while TREM1 level correlated positively with CRP,IL-8 and TNF-α levels(P<0.05).The area under the curve(AUC)of combined detection of CCK-8 and TREM1 in the diagnosis for infection after cholecystectomy was significantly higher than that of each index alone(Z=5.703,P<0.001;Z=4.584,P<0.001).Having gallstones and gallbladder surrounding effusio

关 键 词：急性胆囊炎 胆囊收缩素-8 髓系细胞触发受体1 感染 酶联免疫吸附试验 胆囊切除术 

分 类 号：R446.9[医药卫生—诊断学] R657.41[医药卫生—临床医学]