孕早期及孕中期血清PP-13和ADMA对子痫前期孕妇分娩方式的预测价值  

Predictive value of serum PP-13 and ADMA in early and middle pregnancy on delivery mode in pregnant women with preeclampsia

作　　者：沈丽丹[1] SHEN Lidan(Department of Obstetrics,Zhangjiagang First People's Hospital,Zhangjiagang,Jiangsu 215600,China)

机构地区：[1]江苏省张家港市第一人民医院产科,江苏张家港215600

出　　处：《检验医学与临床》2024年第17期2508-2511,2516,共5页Laboratory Medicine and Clinic

基　　金：江苏省张家港市科技计划项目(ZKS1939)。

摘　　要：目的分析孕早期、孕中期血清半乳糖凝集素-13(PP-13)、非对称性二甲基精氨酸(ADMA)对子痫前期孕妇分娩方式的预测价值。方法回顾性收集2020年1月至2022年12月在该院产科分娩的120例孕妇的临床资料,其中子痫前期孕妇76例,按照子痫前期严重程度分为轻度组52例、重度组24例,另选取同期正常孕妇44例作为对照组,采用酶联免疫吸附试验(ELISA)检测PP-13和ADMA水平。比较3组研究对象PP-13、ADMA水平,比较不同分娩方式孕妇PP-13、ADMA水平,绘制受试者工作特征(ROC)曲线分析PP-13、ADMA预测子痫前期孕妇分娩方式的效能。结果孕早期及孕中期PP-13水平均为重度组<轻度组<对照组,且任意两组间比较,差异均有统计学意义(P<0.05);而孕早期及孕中期ADMA水平均为重度组>轻度组>对照组,且任意两组间比较,差异有统计学意义(P<0.05)。剖宫产比例为重度组>轻度组>对照组,自然分娩比例及阴道助产比例为重度组<轻度组<对照组,且任意两组间比较,差异均有统计学意义(P<0.05)。自然分娩孕妇孕早期、孕中期PP-13水平均高于其他分娩方式孕妇,ADMA水平均低于其他分娩方式孕妇,差异均有统计学意义(P<0.05)。ROC曲线分析显示,孕早期PP-13、孕早期ADMA、孕中期PP-13、孕中期ADMA预测子痫前期孕妇自然分娩的曲线下面积(AUC)分别为0.806、0.963、0.781、0.673。结论孕早期PP-13、孕早期ADMA、孕中期PP-13可能可以用于子痫前期孕妇分娩方式的预测。Objective To analyze the predictive value of galectin-13(PP-13)and asymmetric dimethylarginine(ADMA)in the first and second trimesters of pregnancy for delivery mode in pregnant women with preeclampsia.Methods The clinical data of 120 pregnant women who delivered in the Department of Obstetrics in Zhangjiagang First People's Hospital from January 2020 to December 2022 were collected retrospectively,including 76 pregnant women with preeclampsia.According to the severity of preeclampsia,they were divided into mild group(52 cases)and severe group(24 cases),and 44 normal pregnant women were selected as the control group.The levels of PP-13 and ADMA were detected by enzyme-linked immunosorbent assay(ELISA).The levels of PP-13,ADMA in the three groups and women with different ways childbirth were compared,the receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of PP-13 and ADMA in the first and second trimesters of pregnancy for delivery mode in patients with preeclampsia.Results The levels of PP-13 in the severe group,the mild group and the control group increased in turn in the first and second trimester of pregnancy,the differences between each two groups were statistically significant(P<0.05).The level of ADMA in the severe group,the mild group and the control group decreased successively in the first and second trimester of pregnancy,the differences between each two groups were statistically significant(P<0.05).The proportion of cesarean section in the severe group,the mild group and the control group decreased in turn,and the proportion of natural delivery and viginal assisted delivery in the severe group,the mild group and the control group increased in turn,the differences were statistically significant(P<0.05).The levels of PP-13 in the first and second trimester of pregnant women with natural delivery were higher than those in pregnant women with other delivery modes,and the levels of ADMA in the second trimester of pregnant women with natural delivery were lower than those i

关 键 词：孕早期 孕中期 半乳糖凝集素-13 非对称性二甲基精氨酸 子痫前期 分娩方式 

分 类 号：R446.9[医药卫生—诊断学] R714.2[医药卫生—临床医学]