甘草锌颗粒联合消旋卡多曲治疗病毒感染性肠炎患儿的效果  

Effect of Licorzine Granules Combined with Racecadotril in the Treatment of Viral Infectious Enteritis in Children

作　　者：卢玲玲 LU Lingling(Nanping Maternal and Child Health Care Hospital,Nanping 353000,China)

机构地区：[1]南平市妇幼保健院,福建南平353000

出　　处：《中外医学研究》2024年第23期55-58,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析甘草锌颗粒联合消旋卡多曲治疗病毒感染性肠炎患儿的效果。方法:选取2021年6月—2023年6月南平市妇幼保健院收治的260例病毒感染性肠炎患儿作为研究对象,通过随机数表法将其分为研究组(n=130)与对照组(n=130)。对照组接受消旋卡多曲治疗,研究组接受甘草锌颗粒结合消旋卡多曲治疗,比较两组临床疗效、临床症状消失时间、免疫球蛋白、炎症因子及肠道菌群。结果:研究组总有效率为96.15%,明显高于对照组的84.62%,差异有统计学意义(χ^(2)=8.6740,P=0.0032)。与对照组比较,研究组临床症状消失时间明显更短,差异有统计学意义(P<0.05)。治疗后,两组免疫球蛋白M(IgM)、免疫球蛋白G(IgG)及免疫球蛋白A(IgA)水平及大肠埃希菌、乳杆菌、双歧杆菌数量较治疗前升高,且研究组高于对照组,两组白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平较治疗前降低,且研究组低于对照组,差异有统计学意义(P<0.05)。结论:病毒感染性肠炎患儿应用甘草锌颗粒联合消旋卡多曲治疗,能提高临床效果,改善肠道菌群及免疫球蛋白水平,有效减轻炎症反应。Objective:To analyze the effect of Licorzine Granules combined with Racecadotril in the treatment of viral infectious enteritis in children.Method:A total of 260 children with viral infectious enteritis who admitted to Nanping Maternal and Child Health Care Hospital from June 2021 to June 2023 were selected as the research objects,they were divided into the study group(n=130)and the control group(n=130)by random number table method.The control group was treated with Racecadotril,and the study group was treated with Licorzine Granules combined with Racecadotril.The clinical efficacy,disappearance time of clinical symptoms,immunoglobulin,inflammatory factors and intestinal flora were compared between two groups.Result:The total effective rate of the study group was 96.15%,which was significantly higher than 84.62%of the control group,the difference was statistically significant(χ^(2)=8.6740,P=0.0032).Compared with the control group,the disappearance time of clinical symptoms in the study group was significantly shorter,and the difference was statistically significant(P<0.05).After treatment,the levels of immunoglobulin M(IgM),immunoglobulin G(IgG)and immunoglobulin A(IgA)and the numbers of Escherichia coli,Lactobacillus and Bifidobacterium in two groups were higher than those before treatment,and those in the study group were higher than those in the control group.the levels of interleukin-6(IL-6),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Licorzine Granules combined with Racecadotril in children with viral infectious enteritis can improve the clinical effect,improve the intestinal flora and immunoglobulin levels,and effectively reduce the inflammatory response.

关 键 词：病毒感染性肠炎 甘草锌颗粒 消旋卡多曲 

分 类 号：R725.7[医药卫生—儿科]