新生儿缺氧缺血性脑病影响因素分析  

Analysis of Influencing Factors of Neonatal Hypoxic Ischemic Encephalopathy

作　　者：谢毅 陈华青 王锦 陈佳文 傅嘉婧 XIE Yi;CHEN Huaqing;WANG Jin;CHEN Jiawen;FU Jiajing(Longyan First Hospital Affiliated to Fujian Medical University,Longyan 364000,China;不详)

机构地区：[1]福建医科大学附属龙岩第一医院,福建龙岩364000

出　　处：《中外医学研究》2024年第23期168-171,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨新生儿缺氧缺血性脑病(HIE)影响因素。方法:回顾性选取2014年2月—2022年2月福建医科大学附属龙岩第一医院收治的69例HIE患儿纳入HIE组,同期未发生HIE的84例健康新生儿纳入非HIE组。调查所有新生儿一般资料。对HIE影响因素进行单因素及多因素分析。结果:HIE组妊娠期高血压疾病、妊娠期糖尿病、羊水污染、胎盘早剥、血性羊水、胎膜早破、胎儿宫内窘迫占比均高于非HIE组,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,羊水污染、胎盘早剥、血性羊水、胎膜早破、胎儿宫内窘迫均是HIE的独立危险因素(P<0.05)。结论:新生儿HIE的发生与胎儿宫内窘迫、羊水污染、胎盘早剥、血性羊水、胎膜早破有关。临床应加强孕妇的孕期保健和监护工作,及时进行健康宣教,重视孕妇产前检查,密切关注羊水性状改变,避免胎儿宫内窘迫及新生儿窒息的发生。Objective:To explore the influencing factors of neonatal hypoxic ischemic encephalopathy(HIE).Method:Sixtynine children with HIE admitted to Longyan First Hospital Affiliated to Fujian Medical University from February 2014 to February 2022 were retrospectively selected into the HIE group,and 84 healthy newborns without HIE during the same period were included in the nonHIE group.General information of all newborns was investigated.The influence factors of HIE were analyzed by single factor and multiple factor.Result:The proportions of hypertensive diseases during pregnancy,gestational diabetes mellitus,amniotic fluid contamination,placental abruption,hemorrhagic amniotic fluid,premature rupture of membranes and fetal distress in HIE group were higher than those in non-HIE group,the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that amniotic fluid contamination,placental abruption,bloody amniotic fluid,premature rupture of membranes and fetal distress were independent risk factors for HIE(P<0.05).Conclusion:Neonatal HIE is related to fetal distress,amniotic fluid contamination,placental abruption,bloody amniotic fluid and premature rupture of membranes.In clinic,we should strengthen pregnant women's health care and monitoring work during pregnancy,conduct health education in time,pay attention to prenatal examination of pregnant women,pay close attention to changes in amniotic fluid traits,and avoid intrauterine fetal distress and neonatal asphyxia.

关 键 词：新生儿缺氧缺血性脑病 羊水污染 胎盘早剥 妊娠期糖尿病 

分 类 号：R722.1[医药卫生—儿科]