外周血IL-6、IL-10、SIRI在细菌性肺炎感染患者中的表达特征  

Expression characteristics of IL-6,IL-10 and SIRI in peripheral blood of patients with bacterial pneumonia infection

作　　者：冯宁 陈帅 窦明月 李英超 王建红 乔彩霞 赵顺锋 FENG Ning;CHEN Shuai;DOU Mingyue;LI Yingchao;WANG Jianhong;QIAO Caixia;ZHAO Shunfeng(Laboratory Department,the Third People's Hospital in Liaocheng,Liaocheng 252000,China;Critical Care Medicine Department,the Third People's Hospital in Liaocheng,Liaocheng 252000,China)

机构地区：[1]聊城市第三人民医院检验科,山东聊城252000 [2]聊城市第三人民医院重症医学科,山东聊城252000

出　　处：《临床医学研究与实践》2024年第25期18-21,共4页Clinical Research and Practice

摘　　要：目的探讨细菌性肺炎感染患者外周血炎症指标的表达特征,分析其与疾病严重程度的关系。方法选取2023年1月至2024年1月就诊于聊城市第三人民医院的50例重症肺炎(SP)患者作为SP组,选取同期住院的43例非重症肺炎(NSP)患者作为NSP组和30例健康体检者作为健康对照(HC)组。比较三组的肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)水平及中性粒细胞与淋巴细胞比率(NLR)、血小板与淋巴细胞比值(PLR)、单核细胞与淋巴细胞的比值(MLR)、全身免疫炎症指数(SII)和全身炎症反应指数(SIRI)。采用多因素Logistic回归分析探究SP发生的影响因素,以受试工作者特征(ROC)曲线评价相关指标对SP的诊断效能。结果NSP组和SP组的IL-6、IL-10、hs-CRP水平及NLR、PLR、MLR、SII、SIRI显著高于HC组,差异具有统计学意义(P<0.05);SP组的IL-6、IL-10、hs-CRP、PCT水平及NLR、SII、SIRI显著高于NSP组,差异具有统计学意义(P<0.05);SP组的PCT水平显著高于HC组,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,IL-6、IL-10、SIRI是SP发生的独立危险因素(P<0.05)。ROC曲线分析显示,IL-6、IL-10、SIRI单独诊断SP的曲线下面积(AUC)分别为0.918、0.793、0.719;IL-6+IL-10+SIRI联合诊断SP的AUC为0.952,灵敏度为87.76%,特异度为92.86%。结论外周血炎症指标的检测有助于评估细菌性肺炎患者病情严重程度。IL-6、IL-10、SIRI是SP发生的独立危险因素,三者联合对于SP的诊断价值更高。Objective To investigate the expression characteristics of peripheral blood inflammatory markers in patients with bacterial pneumonia infection,and to analyze its relationship with the severity of the disease.Methods Fifty patients with severe pneumonia(SP)who were admitted in the Third People's Hospital in Liaocheng from January 2023 to January 2024 were selected as SP group,and 43 patients with non-severe pneumonia(NSP)who were hospitalized during the same period were selected as NSP group and 30 healthy physical examination stations were selected as healthy control(HC)group.The levels of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-2(IL-2),interleukin-4(IL-4),interleukin-6(IL-6),interleukin-10(IL-10),high sensitivity C-reactive protein(hs-CRP)and procalcitonin(PCT)and neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio(MLR),systemic immune-inflammation index(SII)and systemic inflammation response index(SIRI)were compared among the three groups.Multivariate Logistic regression analysis was used to analyze the influencing factors of SP,and the receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of related indicators for SP.Results The levels of IL-6,IL-10,hs-CRP and NLR,PLR,MLR,SII,SIRI in the NSP group and the SP group were significantly higher than those in the HC group,and the differences were statistically significant(P<0.05);the levels of IL-6,IL-10,hs-CRP,PCT,NLR,SII and SIRI in the SP group were significantly higher than those in the NSP group,and the differences were statistically significant(P<0.05);the PCT level of the SP group was significantly higher than that of the HC group,and the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that IL-6,IL-10 and SIRI were independent risk factors for SP(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of IL-6,IL-10 and SIRI alone diagnosed SP were 0.918,0.793 and 0.719,respectively;the AUC

关 键 词：细菌性肺炎 白细胞介素-6 白细胞介素-10 全身炎症反应指数 

分 类 号：R563.1[医药卫生—呼吸系统]