替格瑞洛联合非洛地平治疗冠心病心绞痛的效果及对COMP、LTBP-2表达的影响  

Effect of ticagrelor combined with felodipine on angina pectoris of coronary heart disease and its influences on expression of COMP and LTBP-2

作　　者：吴钊 黄家欣 WU Zhao;HUANG Jiaxin(Xi'an No.5 Hospital,Xi'an 710082,China)

机构地区：[1]西安市第五医院,陕西西安710082

出　　处：《临床医学研究与实践》2024年第25期42-45,共4页Clinical Research and Practice

摘　　要：目的探讨替格瑞洛联合非洛地平治疗冠心病心绞痛的效果及对软骨寡聚基质蛋白(COMP)、潜在转化生长因子结合蛋白2(LTBP-2)表达的影响。方法选择2021年1月至2022年7月收治的84例冠心病心绞痛患者为研究对象,以随机数字表法将其分为对照组与观察组,各42例。两组均给予常规治疗,在此基础上对照组采取非洛地平治疗,观察组采取替格瑞洛联合非洛地平治疗。比较两组的治疗效果。结果观察组的治疗总有效率明显高于对照组(P<0.05)。治疗后,观察组的心绞痛发作频率低于对照组,心绞痛发作持续时间短于对照组(P<0.05)。治疗后,观察组的每搏输出量(SV)、心排血量(CO)、二尖瓣舒张早期血流峰值速度/舒张晚期血流峰值速度比值(E/A)高于对照组(P<0.05)。治疗后,观察组的COMP、LTBP-2水平低于对照组(P<0.05)。结论替格瑞洛联合非洛地平治疗冠心病心绞痛的效果显著,可有效降低心绞痛发作频率,缩短发作持续时间,改善心功能,降低COMP、LTBP-2水平,值得推广。Objective To investigate the effect of ticagrelor combined with felodipine on angina pectoris of coronary heart disease and its influences on expression of cartilage oligomeric matrix protein(COMP)and latent transforming growth factor binding protein 2(LTBP-2).Methods A total of 84 patients with angina pectoris of coronary heart disease admitted from January 2021 to July 2022 were selected as the research objects and divided into control group and observation group by random number table method,with 42 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with felodipine,and the observation group was treated with ticagrelor combined with felodipine.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the frequency of angina pectoris in the observation group was lower than that in the control group,and the duration of angina pectoris was shorter than that in the control group(P<0.05).After treatment,stroke volume(SV),cardiac output(CO)and ratio of peak early diastolic flow velocity to peak atrial diastolic flow velocity(E/A)in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of COMP and LTBP-2 in the observation group were lower than those in the control group(P<0.05).Conclusion The ticagrelor combined with felodipine in the treatment of angina pectoris of coronary heart disease has a significant effect,it can effectively reduce the frequency of angina pectoris,shorten the duration of attack,improve cardiac function,and reduce the levels of COMP and LTBP-2,which is worth promoting.

关 键 词：替格瑞洛 非洛地平 冠心病心绞痛 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]