1990~2019年中国和全球归因于Ω-3多不饱和脂肪酸摄入不足的缺血性心脏病疾病负担分析  

The disease burden of ischemic heart disease attributed to insufficient intake of omega-3 polyunsaturated fatty acids in China and the World from 1990 to 2019

作　　者：郑资辉 魏成 徐瑶[1,2,3] 张记收 王梦龙 Zheng Zihui;Wei Cheng;Xu Yao;Zhang Jishou;Wang Menglong(Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan,430060,China;不详)

机构地区：[1]武汉大学人民医院心内科,武汉430060 [2]武汉大学心血管病研究所,武汉430060 [3]心血管病湖北省重点实验室,武汉430060

出　　处：《中国循证心血管医学杂志》2024年第6期681-685,共5页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：国家自然科学基金(82100292);国家级大学生创新创业训练计划项目(202110486083,202210486116)。

摘　　要：目的分析1990~2019年中国和全球居民归因于Ω-3多不饱和脂肪酸(Ω3-PUFA)摄入不足的缺血性心脏病(IHD)疾病负担及变化情况。方法利用2019年全球疾病负担数据,选取年龄标化死亡率、标化伤残调整寿命年(DALY)率和平均年度百分比变化率(AAPC)等指标,对1990~2019年中国和全球居民归因疾病负担状况及变化趋势进行分析。结果2019年中国居民归因于Ω3-PUFA摄入不足的IHD标化死亡率为4.32/10万,标化DALY率为75.93/10万;而全球归因标化死亡率和DALY率分别为4.32/10万和90.65/10万。与1990年相比,2019年中国归因于Ω3-PUFA摄入不足的IHD标化死亡率升高12.88%,DALY率降低3.58%;而全球归因标化死亡率和DALYs率均较1990年下降,分别降低31.10%和28.74%。2019年中国归因标化死亡率和DALY率均表现为男性高于女性(5.77/10万vs.3.36/10万、102.10/10万vs.53.52/10万),且均随年龄增长而升高。1990~2019年,中国归因疾病负担整体呈先上升后下降趋势,归因标化死亡率AAPC为0.4%(95%CI:0.2%~0.6%,P<0.05),而DALY率AAPC为-0.1%(95%CI:-0.3%~0%,P<0.05)。结论在全球Ω3-PUFA摄入不足所致IHD疾病负担明显下降的背景下,中国在控制相关疾病负担方面仍有不足。适当补充Ω3-PUFA可能改善IHD疾病负担。Objective To study the burden and trend of ischemic heart disease(IHD)attributed to insufficient omega-3 polyunsaturated fatty acids(Ω3-PUFA)in China and the World from 1990 to 2019.Method Based on the data of 2019 global burden of disease,the age-standardized mortality rate,age-standardized disability-adjusted life year(DALY)rate,and annual average percentage change(AAPC)were used to analyze the status and trend of attributable disease burden in China and the World from 1990 to 2019.Results In 2019,the age-standardized mortality rate of IHD attributed to insufficient intake ofΩ3-PUFA in Chinese residents was 4.32/100,000,and the standardized DALY rate was 75.93/100,000,while the global attributable standardized mortality rate and standardized DALY rate were 4.32/100,000 and 90.65/100,000,respectively.Compared with 1990,the standardized mortality rate of IHD attributed to insufficient intake ofΩ3-PUFA in 2019 in China increased by 12.88%,while the standardized DALY rate decreased by 3.58%.At the global level,both the attributable standardized mortality rate and the standardized DALY rate in 2019 showed a downward trend compared with 1990,by 31.10%and 28.74%,respectively.In 2019,the attributable standardized mortality and DALY rate in China were higher in males than in females(5.77/100,000 vs.3.36/100,000,102.10/100,000 vs.53.52/100,000),and both showed an upward trend with age.From 1990 to 2019,the disease burden of IHD attributed to insufficient intake ofΩ3-PUFA in China increased at first and then decreased;the AAPC of attributable standardized mortality rate in China was 0.4%(95%CI:0.2%-0.6%,P<0.05),and the AAPC of attributable standardized DALY rate was-0.1%(95%CI:-0.3%-0%,P<0.05).Conclusion Compared with the current situation where the IHD disease burden caused by insufficientΩ3-PUFA intake in the world is significantly reduced,China still has deficiencies in controlling the related disease burden.Proper supplement ofΩ3-PUFA may improve the disease burden of IHD.

关 键 词：Ω-3多不饱和脂肪酸 死亡率 伤残调整寿命年 疾病负担 疾病预防 

分 类 号：R540.83[医药卫生—心血管疾病]