超声实时剪切波弹性成像在血吸虫病肝纤维化诊断应用分析  

Application Analysis of Real-Time Ultrasound Shear Wave Elastography in the Diagnosis of Liver Fibrosis in Schistosomiasis

作　　者：吴婵娟 WU Chan-juan(Inspection Department,Jiangxi Province Nanchang Xinjian District Blood Control Station,Jiangxi Nanchang 330000)

机构地区：[1]江西省南昌市新建区血防站检验科,江西南昌330000

出　　处：《中国医疗器械信息》2024年第15期117-119,共3页China Medical Device Information

摘　　要：目的:探究分析超声实时剪切波弹性成像在血吸虫病肝纤维化诊断应用效果和价值。方法:抽取2022年1月~2023年3月本院接收的血吸虫病肝纤维化患者100例为观察对象,对所有患者进行肝组织活检,将其以纤维化分期的标准进行分组,S0期26例,S1期22例,S2期15例,S3期18例,S4期19例,五组患者均实施超声实时剪切波弹性成像检查,观察比较五组患者的弹性模量、相关血清肝纤维化指标和其诊断效能。结果:①在检查后发现,相较于S0期的患者,S1、S2、S3、S4期患者的弹性模量均更高,数据比较有统计学意义(P<0.05);②在血清肝纤维化指标的比较中,层黏蛋白和透明质酸两项指标,相较于S0期的患者,S1、S2、S3、S4期患者的水平参数更高,数据比较有统计学意义(P<0.05);而Ⅳ型胶原和Ⅲ型前胶原两项指标,相较于S0期的患者,S1、S2、S3、S4期患者的水平参数也较高,但数据比较无统计学意义(P>0.05);③肝实质弹性模量对肝纤维化不同分期组的诊断效能都不同,其中,S1-S4期的诊断效能最高,其阈值和曲线下面积分别为6.80kPa、0.939。结论:超声实时剪切波弹性成像在血吸虫病肝纤维化诊断应用效果显著,有助于明确病理分期,可帮助后期治疗提供准确的诊断依据,是一种应用价值较高的诊断方式。Objective:To explore and analyze the application effect and value of real-time ultrasound shear wave elastography in the diagnosis of liver fibrosis in schistosomiasis.Methods:A total of 100 patients with liver fibrosis caused by schistosomiasis who were admitted to our hospital between January 2022 and March 2023 were selected as the observation subjects.Liver tissue biopsies were performed and divided into groups based on fibrosis staging criteria,with S0=26,S1=22,S2=15,S3=18,and S4=19.All five groups of patients underwent real-time shear wave elastography using ultrasound.The elastic modulus,relevant serum liver fibrosis indicators,and diagnostic efficacy of the five groups of patients were observed and compared.Results:①After examination,it was found that compared to patients in stage S0,patients in stages S1,S2,S3,and S4 all had higher elastic moduli,and the data comparison was statistically significant(P<0.05);②In the comparison of serum liver fibrosis indicators,the levels of laminin and hyaluronic acid were higher in patients in stages S1,S2,S3,and S4 compared to patients in stage S0,and the data comparison was statistically significant(P<0.05);Compared to patients in stage S0,patients in stages S1,S2,S3,and S4 had higher levels of typeⅣcollagen and typeⅢprocollagen,but the data comparison was not statistically significant(P>0.05);③The diagnostic efficacy of liver parenchymal elastic modulus for different stages of liver fibrosis varies,with the highest diagnostic efficacy observed in stages S1-S4,with thresholds and AUC of 6.80kPa and 0.939,respectively.Conclusion:Real time shear wave elastography using ultrasound has a significant diagnostic effect on liver fibrosis in schistosomiasis,which helps to clarify pathological staging and provides accurate diagnostic basis for later treatment.It is a diagnostic method with high application value.

关 键 词：血吸虫病 肝纤维化 超声实时剪切波弹性成像 诊断价值 

分 类 号：R445.1[医药卫生—影像医学与核医学]