基于“脾-内质网相关”学说探讨巨噬细胞焦亡与动脉粥样硬化相关性  

Relationship between macrophage pyroptosis and atherosclerosis based on theory of"spleen in correlation with endoplasmic reticulum"

作　　者：谭咪 刘悦[1] 徐宁阳[1] 韩晓萌 赵誉 刘粽 蔡媛媛 李子威 徐子鉴 TAN Mi;LIU Yue;XU Ning-yang;HAN Xiao-meng;ZHAO Yu;LIU Zong;CAI Yuan-yuan;LI Zi-wei;XU Zi-jian(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847

出　　处：《中国中药杂志》2024年第16期4532-4536,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81703970);辽宁省自然科学基金优秀青年基金计划项目(2023JH3/10200016)。

摘　　要：动脉粥样硬化(AS)的中医发病关键在于脾虚所致痰瘀互结,现代医学认为细胞焦亡可导致动脉粥样硬化,而内质网应激已被研究证明促进细胞焦亡的发生。基于“脾-内质网相关”学说,以脾主运化及内质网健运蛋白功能为导向,认为脾虚所致痰瘀互结与内质网应激导致巨噬细胞焦亡促进炎症反应加速AS进展有共通之处。因此,该文深入探究脾虚所致痰瘀互结与内质网应激介导细胞焦亡的关联,从现代医学角度探讨中医脾虚痰瘀互结影响AS的分子机制,有助于丰富“脾-内质网相关”学说,为中医以健脾祛痰化瘀法防治AS提供科研思路,为临床应用健脾中药治疗AS提供丰富的理论基础。The key pathogenesis of atherosclerosis(AS)in traditional Chinese medicine(TCM)lies in the combination of phlegm and stasis due to spleen deficiency.In Western medicine,it is believed that pyroptosis can lead to atherosclerosis,and endoplasmic re-ticulum stress has been shown to promote pyroptosis.According to the theories of"spleen in correlation with endoplasmic reticulum",guided by spleen governing transportation and transformation,and endoplasmic reticulum processing proteins,it is believed that the syndrome of phlegm combined with stasis due to spleen deficiency has similarities with the mechanism of macrophage pyroptosis induced by endoplasmic reticulum stress in accelerating the progression of AS.This study explored the correlation between phlegm combined with stasis due to spleen deficiency and pyroptosis induced by endoplasmic reticulum stress,and then analyzed the modern medical mechanisms of phlegm combined with stasis due to spleen deficiency in mediating atherosclerosis.The discussion enriches the theory of spleen in correlation with endoplasmic reticulum,provides research ideas on the prevention and treatment of AS by invigorating spleen,eliminating phlegm,and resolving stasis,and lays a theoretical foundation for the clinical application of spleen-invigorating TCM in the treatment of AS.

关 键 词：脾-内质网相关 细胞焦亡 动脉粥样硬化 

分 类 号：R259[医药卫生—中西医结合]