叶下珠水提液胃肠促动作用初探  

Preliminary Study on Gastrointestinal Motility of Phyllanthus Urinaria Water Decoction

作　　者：傅劲松 赵中泱 梁生林 FU Jinsong;ZHAO Zhongyang;LIANG Shengin(Ji'an County Traditional Chinese Medicine Hospital,Ji'an Jiangxi 343100,China;Faculty of Medicine,Jinggangshan University,Ji'an Jiangxi 343009,China;School of Health Nursing,Jiangxi New Energy Technology Institute,Xinyu Jiangxi 338000,China.)

机构地区：[1]吉安县中医院,江西吉安343100 [2]井冈山大学医学部,江西吉安343009 [3]江西新能源科技职业学院健康护理学院,江西新余338000

出　　处：《药品评价》2024年第5期532-535,共4页Drug Evaluation

摘　　要：目的对叶下珠水提液胃肠促动作用进行初步探究。方法应用在体小鼠胃排空和小肠向前推进性运动试验法,以及离体的家兔回肠肠管和豚鼠胃试验法,观察叶下珠水提液对动物胃、小肠活动情况的作用。结果相较于正常对照组,叶下珠水提液低、中、高剂量(2.5、5.0、10.0 g生药/kg)组能较明显地减少在体小鼠胃内残留率,也能较明显增加小肠向前推进运动百分比例,差异有统计学意义(P<0.05);在离体实验中,叶下珠水提液给药后明显增加离体家兔回肠肠管平滑肌收缩的幅度,相较于给药前差异有统计学意义(P<0.01),明显增加豚鼠胃底环形肌收缩的振幅和速度,相较于给药前差异也有统计学意义(P<0.01)。结论叶下珠水提液对胃肠具有明显促动作用。Objective To study gastrointestinal motility of phyllanthus urinaria water decoction.Methods The effects on the gastric and intestinal motility of phyllanthus urinaria water decoction were observed by using the experimental methods of gastric emptying and intestinal propulsive movement in mice in vivo,and the experimental methods of rabbit jejunal tube in vitro and guinea pig stomach in vitro.Results Low-dose,medium-dose and high-dose(2.5,5.0,10.0 g/kg)groups of phyllanthus urinaria water decoction were significantly reduced the residual rate in the stomach of mice in vivo,and also significantly increased the percentage of small intestinal forward movement compared to the normal control group,with significant differences(P<0.05).In vitro experiment,after administration of phyllanthus urinaria water decoction,the contraction amplitude of the isolated rabbit intestinal smooth muscle was significantly increased compared with that before administration(P<0.01),and the contraction frequency and amplitude of the guinea pig gastric fundus circular muscle were significantly increased compared with that before the administration,the difference was also statistically significant(P<0.01).Conclusion Phyllanthus urinaria water decoction has obvious effects on gastric emptying and intestinal motility.

关 键 词：叶下珠 水提液 胃肠促动 

分 类 号：R285.5[医药卫生—中药学]