基于核因子E2相关因子2/血红素加氧酶-1信号通路延缓衰老防治绝经后骨质疏松症及药物干预的研究进展  

A review on anti-aging treatment and drug intervention on postmenopausal osteoporosis based on Nrf2/HO-1 signaling pathway

作　　者：姜震 于冬冬[2] 智猛 JIANG Zhen;YU Dongdong;ZHI Meng

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110000

出　　处：《中医临床研究》2024年第15期103-108,共6页Clinical Journal Of Chinese Medicine

基　　金：国家自然基金项目(82374480);辽宁省教育厅科学基金研究项目(L20121);沈阳市科学技术计划(20-205-4-040);沈阳市科学技术计划(21-174-9-02);辽宁中医药大学中医藏象理论及应用教育部重点实验室开放基金(zyzx1908)。

摘　　要：骨质疏松症(Osteoporosis,OP)是绝经后妇女常见疾病,是由于多种因素致全身骨密度下降,微结构破坏,脆性增加,而易于骨折的全身性骨病。2001年美国国立卫生研究院将其定义为以骨强度下降和骨折风险增加为特征的骨骼疾病。研究证明衰老是绝经后骨质疏松症(Post Menopausal Osteoporosis,PMOP)的重要危险因素之一,细胞衰老与机体衰老密切相关,相关研究证明过氧化氢和超氧化物等活性氧(Reactive Oxygen Species,ROS)是细胞衰老的重要诱因,并且自由基生物学领域的传统观点认为,ROS是氧化应激(Oxidative Stress,OS)的主要原因。目前临床工作中常用的治疗PMOP的药物如双膦酸盐、甲状旁腺激素等存在或多或少的不良反应,中医药作为中国传统文化的瑰宝,相比于PMOP的主流治疗方式具有众多的靶点、更多的有效成分,以及可以从整体观念来出发,宏观的调节身体机能,缓解该疾病导致的诸多疾病。相关研究表明核因子类红细胞2相关因子2(Nuclear Factor Erythroid 2-related Factor 2,Nrf2)与血红素加氧酶-1(Heme Oxygenase-1,HO-1)可以通过消除ROS及抗炎等相关作用来调控OS的损伤,因此,文章将中医基础理论与现代医学分子层面相结合,探究通过调控Nrf2/HO-1信号通路干预OS以延缓衰老来预防PMOP的相关机制。Osteoporosis is a common disease in postmenopausal women,which is a systemic bone disease that is prone to fracture due to a decrease in systemic bone density,microstructural destruction,and increased fragility caused by a variety of factors.In 2001,the National Institutes of Health defined it as a bone disorder characterized by decreased bone strength and an increased risk of fractures.Studies have proved that aging is one of the important risk factors for postmenopausal osteoporosis,cellular aging is closely related to body aging.Related studies have proved that hydrogen peroxide and superoxide and other reactive oxygen species are important triggers of cell aging.In addition,the traditional view in the field of free radical biology believes that reactive oxygen species is the main cause of oxidative stress.Relevant studies have shown that nuclear factor erythroid 2-related factor 2(Nrf2)and heme oxygenase-1(HO-1)can regulate the damage caused by oxidative stress by eliminating reactive oxygen species and anti-inflammatory effects.Therefore,this paper combines the basic theory of traditional Chinese medicine with the molecular level of modern medicine,and explores the mechanism of preventing postmenopausal osteoporosis by regulating Nrf2/HO-1 signaling pathway and intervening oxidative stres.

关 键 词：绝经后骨质疏松症 衰老 氧化应激 核因子类红细胞2相关因子2/血红素加氧酶-1 

分 类 号：R271.9[医药卫生—中西医结合]