儿童非伤寒沙门菌胃肠炎抗感染治疗研究进展  

Research Progress on Anti-Infective Treatment of Non-Typhoid Salmonella Gastroenteritis in Children

作　　者：李高芬 李俊[2] 邱秀燕 杨雅 LI Gaofen;LI Jun;QIU Xiuyan;YANG Ya(The Second Affiliated Hospital of Army Medical University,Chongqing,China 400037;Children's Hospital of Chongqing Medical University·National Clinical Research Center for Child Health and Disorders·Ministry of Education Key Laboratory of Child Development and Disorders·Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity,Chongqing,China 401122)

机构地区：[1]中国人民解放军陆军军医大学第二附属医院,重庆400037 [2]重庆医科大学附属儿童医院·国家儿童健康与疾病临床医学研究中心·儿童发育疾病研究教育部重点实验室·儿童感染与免疫罕见病重庆市重点实验室,重庆401122

出　　处：《中国药业》2024年第17期152-152,I0001-I0005,共6页China Pharmaceuticals

基　　金：重庆市科卫联合医学科研项目[2024MSXM177]。

摘　　要：目的为儿童非伤寒沙门菌(NTS)胃肠炎抗感染治疗提供参考。方法采用计算机检索PubMed,Web of Science,The Cochrane Library和中国知网数据库中自建库起至2023年12月的儿童NTS胃肠炎抗感染治疗相关文献,从NTS的微生物学特点、流行病学、耐药性及抗感染治疗方案进行总结。结果儿童是NTS感染的高危人群;在非免疫缺陷情况下,儿童NTS胃肠炎感染程度通常较轻,具有自限性,无须治疗;重度感染、新生儿和低于3月龄、先天性或医源性免疫缺陷患儿需抗感染治疗。目前,第3代头孢菌素、喹诺酮类和大环内酯类抗菌药物为主要治疗药物,具体用法用量应遵循相关指南,疗程以7~10 d为宜。结论应严格把握儿童NTS胃肠炎抗感染治疗指征,制订合理的抗感染治疗方案,以规范抗菌药物的合理使用,遏制细菌耐药。Objective To provide a reference for the anti-infective treatment of children with non-typhoidal Salmonella(NTS)gastroenteritis.Methods The literature related to anti-infective treatment of children with NTS gastroenteritis in the PubMed,Web of Science,The Cochrane Library,and CNKI were searched from the inception of these databases to December 2023.The microbiological characteristics,epidemiology,drug resistance,and anti-infective treatment plans of NTS were summarized.Results Children are at high risk of NTS infection.In the absence of immunodeficiency,NTS gastroenteritis infection in children is generally mild and self-limiting,without treatment.Anti-infective treatment were required for severe infections,newborns and infants less than three months,and children with congenital or iatrogenic immunodeficiency.At present,the third-generation cephalosporins,quinolone antibiotics and macrolides antibiotics are the main therapeutic drugs,and the specific usage and dosage should follow relevant guidelines.The recommended course of treatment is 7-10 d.Conclusion It is necessary to strictly grasp the indications of anti-infective treatment of children with NTS gastroenteritis and formulate a reasonable anti-infective treatment plan to standardize the rational use of antibiotics,and curb antimicrobial resistance.

关 键 词：儿童 非伤寒沙门菌 胃肠炎 抗感染 进展 

分 类 号：R975[医药卫生—药品]