超脉冲点阵CO_(2)激光联合5%米诺地尔酊治疗斑秃疗效分析  

Effect of Sultra-pulsed Fractional Carbon Dioxide Laser Combined with 5%Minoxidil Tincture in the Treatment of Alopecia Areata

作　　者：徐亚楠[1] 杜宝林[1] 康格格 XU Yanan;DU Baolin;KANG Gege(Department of Dermatology,Yan'an People's Hospital,Yan'an 716000,Shaanxi,China)

机构地区：[1]延安市人民医院皮肤科,陕西延安716000

出　　处：《中国美容医学》2024年第9期83-87,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:研究超脉冲点阵CO_(2)激光联合5%米诺地尔酊治疗斑秃对患者外观美观度及毛发镜检查结果的影响。方法:选取2021年1月-2023年1月延安市人民医院收治的斑秃患者110例分为外用5%米诺地尔治疗的对照组(55例)和联合10600 nm超脉冲点阵CO_(2)激光治疗的观察组(55例),分组方法为随机抽签法,均治疗6周,后随访6个月。统计两组治疗6周后的临床疗效、随访期间复发情况及治疗期间不良反应发生情况,比较两组斑秃改善情况、外观美观度及治疗前和治疗6周后免疫、炎症指标、毛发镜检查、心理状态、脱发严重程度、生活质量。结果:治疗6周后,观察组总有效率为96.36%,高于对照组81.82%(P<0.05);随访期间,观察组复发率为9.09%,低于对照组23.64%(P<0.05)。观察组毳毛长出时间、毳毛变黑时间短于对照组,治疗6周后新发生长面积、美观度评分高于对照组(P<0.05)。两组治疗6周后外周血CD3^(+)、CD4^(+)水平、CD4^(+)/CD8^(+)、毛发密度、毛囊密度与治疗前比较,升高,观察组高于对照组(P<0.05);外周血CD8^(+)、血清肿瘤坏死因子α(TNF-α)水平、毳毛率及焦虑自评量表(Self-rating anxiety scale,SAS)、抑郁自评量表(Self-rating depression scale,SDS)评分、脱发严重程度评分工具(Severity of alopecia tool,SALT)、皮肤病生活质量指数(Dermatology life quality index,DLQI)评分与治疗前比较,降低,观察组低于对照组(P<0.05)。治疗期间,观察组总不良反应发生率为14.55%,对照组总不良反应发生率为9.09%,组间比较差异无统计学意义(P>0.05)。结论:超脉冲点阵CO_(2)激光联合5%米诺地尔酊可有效改善斑秃,提高患者生活质量,且复发风险低,安全性良好。Objective To study the effect of sultra-pulsed fractional carbon dioxide laser combined with 5%minoxidil tincture on the appearance aesthetics and the results of hair mirror examination of alopecia areata.Methods From January 2021 to January 2023,110 patients with alopecia areata admitted to Yan'an People's Hospital were divided into a control group(55 cases)treated with topical 5%minoxidil and a observation group(55 cases)treated with a combination of 10600 nm ultra pulse carbon dioxide lattice laser.The grouping method was random drawing,and both patients were treated for 6 weeks,followed up for 6 months.The clinical efficacy after 6 weeks of treatment,recurrence during follow-up and adverse reactions during treatment of the two groups were statistically analyzed.The improvement of alopecia areata,aesthetic appearance,immunity,inflammation index,hair mirror examination,mental state,alopecia severity and quality of life were compared between the two groups.Results After 6 weeks of treatment,the total effective rate of the observation group was 96.36%,which was higher than that of the control group(81.82%,P<0.05);During the follow-up period,the recurrence rate of the observation group was 9.09%,lower than that of the control group(23.64%,P<0.05).The dot matrix laser group had shorter hair growth time and blackening time than the control group.After 6 weeks of treatment,the newly developed growth area and the score of aesthetic were higher in the control group than in the control group(P<0.05).After 6 weeks of treatment,the levels of peripheral blood CD3+,CD4+,CD4+/CD8+,hair density,and hair follicle density in both groups increased compared to before treatment.The observation group was higher than the control group(P<0.05);Peripheral blood CD8+and serum tumor necrosis factorα(TNF-α),the scores of the self-rating anxiety scale(SAS),self-rating depression scale(SDS),severity of alopecia tool(SALT),and dermatology life quality index(DLQI)in both groups decreased compared with pre-treatment.The observation group wa

关 键 词：斑秃 超脉冲点阵CO_(2)激光 米诺地尔酊 美观度 毛发镜 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]