儿童颈椎神经弓中心软骨联合形态发育的数字解剖学特征  

Digital anatomical characteristics of morphological development of neurocentral synchondrosis of cervical vertebra in children

作　　者：伊钰营 孙瑞芬[2] 尹兆正 李磊[1] 张凤珍 李梓瑜 李琨 任小燕[5] 王星[3,4] 张少杰 Yi Yuying;Sun Ruifen;Yin Zhaozheng;Li Lei;Zhang Fengzhen;Li Ziyu;Li Kun;Ren Xiaoyan;Wang Xing;Zhang Shaojie(Graduate School,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Imaging Center,Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,Inner Mongolia Autonomous Region,China;Department of Human Anatomy,School of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Digital Medical Center,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Department of Endocrinology,Affiliate Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia Autonomous Region,China)

机构地区：[1]内蒙古医科大学研究生院,内蒙古自治区呼和浩特市010110 [2]内蒙古医科大学第二附属医院影像中心,内蒙古自治区呼和浩特市010000 [3]内蒙古医科大学基础医学院人体解剖教研室,内蒙古自治区呼和浩特市010110 [4]内蒙古医科大学数字医学中心,内蒙古自治区呼和浩特市010110 [5]内蒙古医科大学附属医院内分泌科,内蒙古自治区呼和浩特市010050

出　　处：《中国组织工程研究》2025年第15期3138-3146,共9页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(82360892),项目负责人:张少杰;内蒙古自治区卫生科技计划项目(202201219),项目负责人:张少杰;内蒙古自治区教育厅科技领先人才和创新团队建设项目(NMGIRT2307),项目负责人:张少杰;内蒙古医科大学重点项目(YKD2022ZD007),项目负责人:张少杰;内蒙古医科大学博士启动基金项目(YKD2023BSQD011),项目负责人:张少杰;2022年内蒙古自治区卫生科技计划项目(202201354),项目负责人:孙瑞芬。

摘　　要：背景:随着国内外学者对儿童颈椎相关疾病重视程度的提升,探知不同年龄儿童颈椎形态发育解剖学指标及变化规律的需求不断提高。目的:通过测量1-6岁儿童C_(2)-C_(7)神经弓中心软骨联合解剖学位置指标,探讨及分析儿童不同年龄和椎序间形态发育的变化规律。方法:回顾性收集了省级三甲医院1-6岁儿童正常颈椎CT影像资料160例,按照1周岁为一个年龄组分6组,将连续扫描的颈椎断层影像原始数据导入Mimics 16.0软件中,在二维图像窗口下,选择Measurements测量工具分别在冠状面及横断面上对颈椎C_(2)-C_(7)节段神经弓中心软骨联合的解剖学位置指标进行测量和分析。结果与结论:①C_(2)-C_(7)神经弓中心软骨联合两侧间距离、神经弓中心软骨联合左右侧与横突的距离均随着年龄增长逐渐增大,各颈椎节段椎骨整体发育较神经弓中心软骨联合骨化速度快;②C_(2)-C_(7)神经弓中心软骨联合两侧横断面夹角随年龄增长逐渐增大、神经弓中心软骨联合左右侧与椎体前后缘的夹角均逐渐减小,颈椎节段神经弓中心软骨联合两侧趋于向椎弓部位生长,主要促进椎弓的生长发育;③除C_(7)以外,其他椎段随着颈椎下行神经弓中心软骨联合两侧冠状面夹角变化较小,颈椎的神经弓中心软骨联合更偏向于纵向生长与骨化;④C_(7)的神经弓中心软骨联合位置变化与其余颈椎节段有明显差异;⑤儿童C_(2)-C_(7)神经弓中心软骨联合位置解剖学指标在不同年龄段和不同椎体之间有明显发育规律,且这些规律有助于儿童颈椎疾病的临床诊断与治疗。BACKGROUND:With the increasing attention of scholars at home and abroad to children’s cervical spine-related diseases,the demand for exploring the anatomical indicators and changes of cervical spine morphology and development in children of different ages is increasing.OBJECTIVE:To explore and analyze the morphological changes of children with different ages and vertebral sequences by measuring the anatomical position indexes of C_(2)-C_(7) neurocentral synchondrosis in children aged 1-6 years.METHODS:Normal cervical spine CT images were retrospectively collected from 160 children aged 1-6 years at provincial tertiary hospitals.They were divided into six groups according to an age group of 1 year.The raw data of consecutively scanned cervical spine tomography images were imported into Mimics 16.0 software.The positional anatomical indexes of cervical spine segments C_(2)-C_(7) in coronal and transverse planes were measured and analyzed under the twodimensional image window by choosing the measurement tools under the toolbar of Measurements.RESULTS AND CONCLUSION:(1)The distance between the two sides of C_(2)-C_(7) neurocentral synchondrosis and the distance between the left and right sides of neurocentral synchondrosis and the transverse process gradually increased with age.The overall development of vertebrae in each cervical vertebral segment was faster than the ossification of the neurocentral synchondrosis.(2)The cross-sectional angles on both sides of C_(2)-C_(7) neurocentral synchondrosis gradually increased with age,and the angles between the left and right sides of neurocentral synchondrosis and the anterior and posterior edges of the vertebral body gradually decreased.Both sides of the neurocentral synchondrosis in cervical vertebral segments tended to grow toward the arch site,which mainly promoted the growth and development of the arch.(3)Except for C_(7),the angle between the coronal planes on both sides of the cervical spine changed little with the descending neurocentral synchondrosis of the cervi

关 键 词：儿童 颈椎 颈椎疾病 神经弓中心软骨联合 形态发育 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R681