A Registry-Based Observational Study on the Maternal and Fetal Outcomes of COVID-19 Patients in Hong Kong,China  

作　　者：Hillary HY Leung Teresa WL Ma Florrie NY Yu Meliza CW Kong Tsz Kin Lo Pauline PL So Wing-Cheong Leung Wendy Shu Ka Wang Cheung Sakita Moungmaithong Chi Chiu Wang Liona C.Poon 

机构地区：[1]Department of Obstetrics and Gynaecology,The Chinese University of HongKong,Hong Kong 999077,China [2]Department of Obstetrics and Gynaecology,Queen Elizabeth Hospital,Hong Kong 999077,China [3]Department of Obstetrics and Gynaecology,United Christian Hospital,Hong Kong 999077,China [4]Department of Obstetrics and Gynaecology,Princess Margaret Hospital,Hong Kong 999077,China [5]Department of Obstetrics and Gynaecology,Tuen Mun Hospital,Hong Kong 999077,China [6]Department of Obstetrics and Gynaecology,Kwong Wah Hospital,Hong Kong 999077,China [7]Department of Obstetrics and Gynaecology,Pamela Youde Nethersole Eastern Hospital,Hong Kong 999077,China [8]Department of Obstetrics and Gynaecology,Queen Mary Hospital,Hong Kong 999077,China

出　　处：《Maternal-Fetal Medicine》2024年第3期156-163,共8页母胎医学杂志（英文）

基　　金：supported by funding from Ferring Pharmaceuticals(Saint-Prex,Switzerland).

摘　　要：Objective:To report the clinical maternal and fetal outcomes of pregnant women with coronavirus disease 2019(COVID-19),along with any associated pregnancy complications,in Hong Kong,China,and to assess the impact of COVID-19 vaccination on these outcomes.Methods:This prospective registry-based observational study included pregnant women who were recruited through convenient sampling and had a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection with a cycle threshold(Ct)value result available on admission to eight local hospitals in Hong Kong,China.Data on clinical symptoms,laboratory results,medical treatments,delivery timing and mode,and pregnancy complications were extracted from the Hospital Authority’s electronic medical record system.Maternal,fetal,and pregnancy outcomes were compared between unvaccinated pregnant women with COVID-19 and those who had received at least one dose of COVID-19 vaccine before diagnosis.Nonparametric continuous variables and categorical variables were analyzed using the Mann-Whitney U test and the Pearson’s chi-squared test respectively.A P value less than 0.05 was considered statistically significant.Results:A total of 164 pregnant women were included,of whom 78(47.56%)were nulliparous.COVID-19 was diagnosed before 28 weeks’gestation in 30(18.29%),while 134(81.71%)were diagnosed at or after 28 weeks’gestation.Sixty-two(37.80%)women received at least one dose of COVID-19 vaccine.There were no significant differences between vaccinated and unvaccinated groups in the time interval between COVID-19 diagnosis and delivery,the Ct value,and the gestational age at infection onset or delivery(P>0.05).The majority of women were symptomatic at diagnosis regardless of vaccination status 55(88.71%)in vaccinated group vs.78(76.47%)in unvaccinated group(P=0.052).Symptoms did not significantly differ between groups except for cough(62.90%vs.47.06%,P=0.049).The overall rate of severe COVID-19 in pregnant women was low.In total,5(3.05%)patients experienced severe

关 键 词：COVID-19 Maternal outcomes Fetal outcomes Pregnancy complications Severe COVID-19 

分 类 号：R714.251[医药卫生—妇产科学]