Unique Ultrastructural Alterations in the Placenta Associated With Macrosomia Induced by Gestational Diabetes Mellitus  

作　　者：Junxiang Wei Tianyu Dong Mingxia Chen Xiao Luo Yang Mi 

机构地区：[1]Department of Obstetrics,Northwest Women’s and Children’s Hospital,Xi’an 710061,China [2]Laboratory of Electron Microscope,Health Science Center of Xi’an Jiaotong University,Xi’an 710049,China [3]Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Health Science Center of Xi’an Jiaotong University,Xi’an 710049,China

出　　处：《Maternal-Fetal Medicine》2024年第3期164-172,共9页母胎医学杂志（英文）

基　　金：supported by the research grant from the Key Research and Development Program of Shaanxi Province(no.2022SF-125,2021ZDLSF02-14).

摘　　要：Objective:To investigate the morphological and ultrastructural alterations in placentas from pregnancies with gestational diabetes mellitus(GDM)–induced macrosomia,term nondiabetic macrosomia,and normal pregnancies.Methods:Sixty full-term placentaswere collected,and clinical data alongwith informed consent were obtained from pregnant womenwho underwent regular visit checks and delivered their newborns in Northwest Women’s and Children’s Hospital between May and December 2022.Placentas were divided into three equal groups:normal pregnancy(control group),nondiabetic macrosomia group,and macrosomia complicated with GDM(diabetic macrosomia)group.Gross morphological data of placentas were recorded,and placental samples were processed for examination of ultrastructural and stereological changes using transmission electron microscopy.Analysis of variance and chi-squared test were used to examine the differences among the three groups for continuous and categorical variables,respectively.Results:The baseline characteristics of mothers and neonates did not differ across the three groups,except for a significantly higher birth weight in the diabetic macrosomia group(4172.00±151.20 g vs.3192.00±328.70 g,P<0.001)and nondiabetic macrosomia group(4138.00±115.20 g vs.3192.00±328.70 g,P<0.001)comparedwith control group.Examination of the placentas revealed that placental weight was also highest in the diabeticmacrosomia group comparedwith control group(810.00±15.81 g vs.490.00±51.48 g,P<0.001)and nondiabetic macrosomia group(810.00±15.81 g vs.684.00±62.69 g,P<0.001),but the ratio of neonatal birth weight to placental weight(BW/PW)was significantly lower in the diabetic macrosomia group compared with that in the control group(5.15±0.19 vs.6.54±0.63,P<0.001)and nondiabetic macrosomia group(5.15±0.19 vs.6.09±0.52,P<0.001)group.In contrast,the BW/PW ratio in nondiabetic macrosomia did not differ significantly from that in the control group.Distinct ultrastructural changes in terminal villi and stereological alterat

关 键 词：PLACENTA MACROSOMIA Gestational diabetes mellitus ULTRASTRUCTURE MORPHOLOGY 

分 类 号：R714.256[医药卫生—妇产科学]