卫糖谷膳对2型糖尿病大鼠胰岛素、糖脂代谢以及胰腺病理影响  

Effects of Grains meal of safeguarding blood glucose on insulin,glucose-lipid metabolism and pancreatic pathology in rats with type 2 diabetes mellitus

作　　者：吴艳旭 钟红卫 蒙巍 冉倩虹 刘俊彦 WU Yanxu;ZHONG Hongwei;MENG Wei;RAN Qianhong;LIU Junyan(Luzhou Hospital of Traditional Chinese Medicine,Luzhou,646000,Sichuan;The Affiliated Hospital of Traditional Chinese Medicine,Southwest Medical Universiy,Luzhou 646000,Sichuan;College of Integrative Medicine,Soulhwest Medical University,Luzhou 646000,Sichuan)

机构地区：[1]泸州市中医医院,四川泸州646000 [2]西南医科大学附属中医医院,四川泸州646000 [3]西南医科大学中西医结合学院,四川泸州646000

出　　处：《中药与临床》2024年第3期61-67,共7页Pharmacy and Clinics of Chinese Materia Medica

基　　金：西南医科大学青年基金项目(2020ZRQNA030);四川省干部保健科研项目(川干研2023-2001);泸州市科技计划项目(2023SYF122)。

摘　　要：目的:开展卫糖谷膳对2型糖尿病(T2DM)大鼠胰岛素、糖脂代谢、胰腺病理形态的影响研究,为使用卫糖谷膳提供实验学依据。方法:将40只雄性SD大鼠分为对照组(A组)和普通饲料组(B组),高糖高脂组(C组),卫糖谷膳组(D组),二甲双胍组+卫糖谷膳组(E组),二甲双胍+普通饲料组(F组)。每周测FBG及2h-PG,第2、4周行OGTT,代谢笼内记录饮食、饮水、二便量,4周后取血及胰腺组织,测糖脂、胰岛素及安全指标,胰腺行HE染色。结果:与B、C组相比,D、E组二便量、饮食量减少(P<0.05);与B、C、F组相比,D、E组FINS、QUICKI、HDL-C增加(P<0.05),FBG、2h-PG、TG、LDL-C降低(P<0.05),HOMA-IR、HOMA-β、葡萄糖耐量改善(P<0.05);与B、C、F组相比,D、E组胰腺组织中沉积糖原、淋巴细胞浸润较少,泡心细胞数量更多。结论:卫糖谷膳可改善T2DM大鼠多饮、多食、多尿的症状,改善T2DM大鼠糖脂代谢、胰岛细胞功能、胰腺损伤及炎症反应。Objective:The study of insulin,glucose-lipid metabolism,and pancreatic pathological morphology in type 2 diabetes mellitus(T2DM)rats by the therapeutic formula Grains meal of safeguarding blood glucose provided a basis for the use of Grains meal of safeguarding blood glucose.Methods:Forty male SD rats were divided into control group(group A)and model General feed group(group B),model High sugar and high fat group(group C),Grains meal of safeguarding blood glucose group(group D),metformin group+Grains meal of safeguarding blood glucose group(group E),Metformin+regular feed group(group F).FBG and 2h-PG were measured weekly,and OGTT was performed in the 2nd and 4th weeks.Diet,water intake and diarrhea were recorded in the metabolic cage,and blood and pancreatic tissues were taken after 4 weeks to measure glucose-lipid,insulin and safety indexes.The pancreas was stained with HE.Results:Compared with model groups B and C,excrete volume of stool and urine and diet volume were reduced in groups D and E(P<0.05).Compared with model groups B,C and F,FINS,QUICKI and HDL-C were increased in groups D and E(P<0.05),FBG,2h-PG,TG and LDL-C were reduced(P<0.05),and HOMA-IR,HOMA-β and glucose tolerance were improved(P<0.05).Compared with groups B,C and F,there were less glycogen deposition,less lymphocyte infiltration and more alveolar cells in groups D and E.Conclusion:Grains meal of safeguarding blood glucose can improve the symptoms of polydipsia,polyphagia and polyuria,improve glucose lipid metabolism,pancreatic islet cell function,pancreatic injury and inflammatory response in T2DM rats.

关 键 词：2型糖尿病大鼠 卫糖谷膳 中医食疗 辨证施膳 

分 类 号：R285.5[医药卫生—中药学]