扩散峰度成像对糖尿病视网膜病变患者脑白质微结构改变的研究  

Study on Microstructural Changes of White Matter in Patients with Diabetic Retinopathy Based on DKI Technique

作　　者：徐天野 冯艳泓 孙中茹 田为中[2] 夏建国[2] 陈锦华[2] XU Tianye;FENG Yanhong;SUN Zhongru(Graduate School of Dalian Medical University,Dalian,Liaoning Province 116044,P.R.China)

机构地区：[1]大连医科大学研究生院,116044 [2]泰州市人民医院影像科,225300

出　　处：《临床放射学杂志》2024年第8期1250-1254,共5页Journal of Clinical Radiology

基　　金：江苏省卫健委科研课题项目(编号:H2018093);江苏省第五期“333工程”科研项目(编号:BRA2017175);泰州市311人才工程科研资助项目(编号:RCPY202137)。

摘　　要：目的应用扩散峰度成像(DKI)技术观察糖尿病视网膜病变(DR)患者脑白质微结构的变化模式。方法选取28例DR患者(DR组)及28名与其年龄、性别及教育程度相匹配健康志愿者对照组(HC)进行全脑DKI检查,针对存在差异的白质区域提取相关指标,分析脑白质结构改变与临床资料的相关性。结果与HC组相比,DR组患者在胼胝体膝部、胼胝体体部、胼胝体压部、双侧前、上放射冠、右侧内囊前肢及后肢、右侧额枕上束各向异性分数(FA)值减低(P<0.05)。小脑中脚、双侧内侧皮质脊髓束、双侧内侧丘系、双侧大脑脚、左侧内囊前肢轴向峰度(AK)值均明显增高(P<0.05)。右前放射冠、右上放射冠、胼胝体体部、左侧丘脑后辐射径向峰度(RK)值减低。相关性分析发现,DR组病程与右侧内囊后肢的FA值呈负相关(r=-0.4009,P<0.05)。结论DKI技术能够发现DR患者白质结构的改变,且差异脑区白质结构的改变与患者病程具有一定相关性。Objective Diffusion kurtosis imaging(DKI)was used to observe the microstructural changes of white matter in patients with diabetic retinopathy(DR).Methods A total of 28 patients with DR(DR Group)and 28 healthy volunteers(HC)matched with their age,sex and education level were selected for whole brain DKI examination.Relevant indexes were extracted from the white matter regions with differences,and the correlation between the changes of brain white matter structure and clinical data was analyzed.Results Compared with HC group,the FA value of the knee,corpus callosum body,corpus callosum pressing part,bilateral anterior and superior radiative crown,right anterior and posterior limbs of the internal capsule,and right fronto⁃occipital tract in DR Group were decreased(P<0.05).AK values of cerebellar middle peduncle,bilateral medial corticospinal tract,bilateral medial colliculus,bilateral cerebral peduncle and left anterior capsule were significantly increased(P<0.05).The RK values of the right anterior corona,right upper corona,corpus callosum and left posterior thalamus were decreased.Correlation analysis showed that the course of disease in DR Group was negatively correlated with the FA value of the posterior limb of the right internal capsule(r=-0.400,P<0.05).Conclusion DKI technique can detect the change of white matter structure in DR Patients,and the change of white matter structure in different brain areas has a certain correlation with the disease course of patients.

关 键 词：扩散峰度成像 糖尿病视网膜病变 平均扩散峰度 各向异性分数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R587.2[医药卫生—诊断学] R774.1[医药卫生—临床医学]