甲状腺激素与肝脏/腹部脂肪和骨密度的相关性研究  

Correlation of Thyroid Hormones with Liver/Abdominal Fat and Bone Density

作　　者：陈涛[1] 税小丁 熊飞翔 梁玉龙 郭鹏德[3] CHEN Tao;SHUI Xiaoding;XIONG Feixiang(Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学,100029 [2]中国中医科学院,100700 [3]北京中医药大学东方医院放射科,100078

出　　处：《临床放射学杂志》2024年第8期1398-1403,共6页Journal of Clinical Radiology

基　　金：北京市慢性病防治与健康教育研究会基金资助项目(编号:MB20220301)。

摘　　要：目的应用定量CT(QCT)测量肝脏/腹部脂肪及腰椎骨密度,分别探讨其在男、女性别组与甲状腺激素水平的相关性,同时运用因子分析与R语言绘制相关性热图及受试者工作特征曲线,并计算其曲线下面积(AUC)以评价整体效能。方法将265名健康体检者按性别分为两组,应用QCT测量肝脏/腹部脂肪及腰椎骨密度,搜集甲状腺激素数值,应用统计软件分析其相关性,将分析结果可视化。结果男性组TT4、FT4与肝脏脂肪均存在负相关(TT4:r=-0.164,P=0.045;FT4:r=-0.239,P=0.003);女性促甲状腺激素(TSH)与肝脏脂肪相关(r=0.203,P=0.03),FT3与平均皮下脂肪面积(SAT)存在相关性(r=0.223,P=0.017)。因子分析表明将甲状腺激素、肝脏/腹部脂肪、骨密度指标组合成4个公因子,在男女组中累计贡献率分别为68.06%及65.85%。男性组TSH与腰椎骨密度AUC为0.717,女性组TSH与肝脏脂肪AUC为0.722,约登指数分别为0.551和0.384。结论男、女组的甲状腺激素水平与肝脏脂肪/腹部脂肪均存在不同程度的相关性,结合甲状腺激素指标可能在一定程度上提高脂肪肝、肥胖及骨质疏松的整体判断效能。Objective Quantitative CT(QCT)was applied to measure liver/abdominal fat and lumbar bone mineral density to explore their correlation with thyroid hormone levels in male and female gender groups,respectively,and to evaluate the overall efficacy of the same by using factor analysis and R⁃lingual to draw correlation heatmaps and Receiver Operating Characteristic(ROC)curves,and calculate the Area Under Curve(AUC).Methods 265 health checkups in our physical examination center were divided into two groups according to gender,quantitative CT was applied to measure liver/abdominal fat and lumbar bone mineral density,and thyroid hormone values were collected,and statistical software was applied to analyze the correlation,and the results of the analyses were visualized.Results In the male group,there was a negative correlation between TT4 and FT4 and liver fat(TT4:r=-0.164,P=0.045;FT4:r=-0.239,P=0.003);in the female group,TSH correlated with liver fat(r=0.203,P=0.03),and there was a correlation between FT3 and mean subcutaneous area of fat(SAT)(r=0.223,P=0.017).Factor analysis indicated that combining thyroid hormone,liver/abdominal fat,and bone density indices into four common factors contributed 68.06%and 65.85%cumulatively in the male and female groups,respectively.The AUC of TSH to lumbar spine bone density was 0.717 in the male group,and the AUC of TSH to liver fat was 0.722 in the female group,with Yoden indices of 0.551 and 0.384,respectively.Conclusion Thyroid hormone levels and liver fat/abdominal fat in both male and female groups showed different degrees of correlation,and the combination of thyroid hormone indexes can improve the overall judgment efficacy of fatty liver,obesity and osteoporosis to a certain extent..

关 键 词：定量CT 肝脏/ 腹部脂肪 腰椎骨密度 甲状腺激素 

分 类 号：R589.2[医药卫生—内分泌] R580[医药卫生—内科学]