沙眼衣原体质粒蛋白3致病机制的研究进展  

Research progress on the pathogenesis of Chlamydia trachomatis plasmid gene protein 3

作　　者：吴芯蕾 朱润泽 朱珊丽 Wu Xinlei;Zhu Runze;Zhu Shanli(The Second Clinical School of Medicine,Wenzhou Medical University,Wenzhou 325035,China;School of Optometry(School of Biomedical Engineering),Wenzhou 325035,China;Department of Microbiology and Immunology,School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou 325035,China)

机构地区：[1]温州医科大学第二临床医学院,温州325035 [2]眼视光学院(生物医学工程学院),温州325035 [3]温州医科大学基础医学院微生物学和免疫学教研室,温州325035

出　　处：《国际生物制品学杂志》2024年第4期245-251,共7页International Journal of Biologicals

基　　金：浙江省大学生科技创新活动计划(新苗人才计划)(2023R413026)。

摘　　要：沙眼衣原体(Chlamydia trachomatis,CT)的生殖道感染可导致女性盆腔炎症、输卵管炎症、异位妊娠和不孕等严重并发症,然而其致病机制尚不明确。CT质粒蛋白3(plasmid gene protein 3,Pgp3)的缺失可使CT上行感染致病力减弱、无法诱导上生殖道输卵管的病变,表明Pgp3在CT致病中起重要作用。Pgp3通过抑制宿主细胞凋亡、改善宿主细胞生存状态以及抑制人类抗菌肽等多种机制,维持CT生存并促进其感染上行。Pgp3还可通过促进CT转移并定植于胃肠道,建立CT的持续感染。此外,Pgp3通过诱导产生炎症因子等方式促进炎症的发生发展。因此,Pgp3是CT致病的重要毒力因子。此文就Pgp3对CT致病机制的研究进展作一综述。Genital tract infections with Chlamydia trachomatis(CT)can lead to serious complications including pelvic inflammation,tubal inflammation,ectopic pregnancy,and infertility in females.However,the pathogenesis of CT remains unclear.The deficiency of CT plasmid gene protein 3(Pgp3)reduces the pathogenicity of CT infections in the upper genital tract and prevents the induction of lesions in the upper genital tubes.These suggest that Pgp3 play a significant role in CT pathogenesis.Pgp3 maintains CT survival and promotes its infection uptake through a variety of processes including inhibition of host cell apoptosis,improvement of host cell survival,and inhibition of human antimicrobial peptides.Pgp3 also establishes persistent infection of CT by promoting the transfer and colonization of CT into the gastrointestinal tract.Furthermore,Pgp3 promotes the development of inflammation by inducing the generation of inflammatory factors.Therefore,Pgp3 is an important virulence factor responsible in CT infection.This article summarizes the research progress on the pathogenic mechanism of CT by Pgp3.

关 键 词：沙眼衣原体 质粒 质粒蛋白3 

分 类 号：R374.1[医药卫生—病原生物学]