益生菌抑制断奶仔猪腹泻的作用及机制  

Inhibition Effects and Mechanism of Probiotics on Post-Weaning Diarrhea in Piglets

作　　者：贾冬文 夏子涵 王家莹 曹阳[1,2,3,4] JIA Dongwen;XIA Zihan;WANG Jiaying;CAO Yang(College of Animal Science and Veterinary Medicine,Heilongjiang Bayi Agricultural University,Daqing 163319,China;Engineering Research Center of Processing and Utilization of Grain By-Products,Ministry of Education,Daqing 163319,China;Heilongjiang Provincial Key Laboratory of Efficient Utilization of Feed Resources and Nutrition Manipulation in Cold Region,Daqing 163319,China;Engineering Technology Research Center of Daqing Biological Feed Development and Safe Utilization,Daqing 163319,China)

机构地区：[1]黑龙江八一农垦大学动物科技学院,大庆163319 [2]粮食副产物加工与利用教育部工程研究中心,大庆163319 [3]黑龙江省寒区饲料资源高效利用与营养调控重点实验室,大庆163319 [4]大庆市生物饲料开发与安全利用工程技术研究中心,大庆163319

出　　处：《动物营养学报》2024年第8期4795-4808,共14页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金项目(32171676);齐齐哈尔鹏博饲料科技有限公司合作研发项目(104/2041200038)。

摘　　要：断奶仔猪腹泻是养猪行业的常见疾病,其较高的发病率与死亡率对养猪行业造成较大经济损失。益生菌是一类对动物生命活动有益的微生物,其作为饲料添加剂可起到预防仔猪腹泻,减轻腹泻症状等效果。本文综述了益生菌通过自身增殖并抑制有害微生物保持肠道稳态、产生活性物质巩固肠道屏障、直接或间接与细胞表面受体作用加强肠道免疫能力等方式缓解仔猪腹泻,分析了益生菌对肠道细胞抗炎、抗凋亡的具体作用机制,为充分了解益生菌抑制仔猪腹泻的作用机制及其在仔猪饲养中的应用提供参考。Post-weaning diarrhea is a common disease,and its high morbidity and mortality will cause great economic losses in pig industry.Probiotics are a kind of microorganism beneficial to animal life activities.As feed additives,probiotics can prevent diarrhea and alleviate the diarrhea symptoms of piglets.This paper reviewed the effects of probiotics on relieving diarrhea in piglets by self-proliferation and inhibiting harmful microorganisms to maintain intestinal homeostasis,producing active substances to consolidate intestinal barrier,and directly or indirectly interacting with cell surface receptors to enhance intestinal immunity,analyzed the specific mechanisms of probiotics on anti-inflammatory and anti-apoptosis of intestinal cells,aiming to provide a reference for fully understanding the mechanism of probiotics inhibiting diarrhea in piglets and its application in piglet feeding.

关 键 词：仔猪 腹泻 益生菌 抑制作用 肠道菌群 

分 类 号：S828[农业科学—畜牧学]