结晶驱动共聚类肽在水溶液中自组装制备二维纳米片  

Preparation of Two-dimensional Nanosheets from Crystallization-driven Self-assembly of Copolypeptoids in Aqueous Solution

作　　者：李荣烨 孙静 LI Rongye;SUN Jing(School of Machinery and Automation,Weifang University,Weifang 261061,China;College of Chemistry,Jilin University,Changchun 130015,China)

机构地区：[1]潍坊学院机械与自动化学院,山东潍坊261061 [2]吉林大学化学学院,吉林长春130015

出　　处：《青岛科技大学学报（自然科学版）》2024年第4期91-97,共7页Journal of Qingdao University of Science and Technology:Natural Science Edition

基　　金：山东省自然科学基金项目(ZR2019JQ17).

摘　　要：两亲性嵌段共聚物在水溶液中可以组装形成亲水性部分为外壳,疏水性部分为内核的胶束。通过开环聚合和巯基-烯点击化学制备了侧链含氨基的聚(N-烯丙基甘氨酸)-b-聚(N-正辛基甘氨酸)((PNAG-g-NH_(2))-b-PNOG)两嵌段共聚物,并研究了其在水溶液中的结晶驱动自组装(CDSA)行为,结果表明,由于pH升高,氨基去质子化降低了PNAG-g-NH_(2)的亲水性,胶束的胶体稳定性降低,利于纳米片的形成。同时,缓慢冷却室温后后,由于PNOG结晶,更多纳米片形成,并且该胶束溶液pH调至6.5后,纳米片结构依然存在。通过透射电子显微镜(TEM)观察到二维不规则纳米片。Amphiphilic copolymers can self-assemble into micelles in aqueous solution with hydrophilic segment as corona and the hydrophobic part as inner core.In this work,we synthesized diblock copolypeptoids modified with amino groups poly(N-allylglycine)-b-poly(Noctylglycine)(PNAG-g-NH_(2)-b-PNOG)by ring-opening polymerization and thiol-ene click chemistry,and studied its crystallization-driven self-assembly(CDSA)behaviors in aqueous solution.The results showed that the deprotonation of the amine groups reduces the hydrophilicity of PNAG-g-NH_(2)and the colloidal stability of micelles,which facilitates the formation of nanosheets.Meanwhile,more nanosheets were formed due to the crystallization of PNOG after cooling to room temperature slowly,and the nanosheet structure remained after the pH of the micellar solution was adjusted to 6.5.2D irregular nanosheets were observed by transmission electron microscope(TEM).

关 键 词：聚类肽 开环聚合 结晶驱动自组装 纳米片 

分 类 号：O631.2[理学—高分子化学]