3-氯-4-氟苯胺的合成及其应用  

Synthesis and Application of 3-chlorine-4-flunaniline

作　　者：艾祖国 范吉霞 李一明 李兴 字慧敏 田强 Ai Zuguo;Fan Jixia;Li Yiming;Li Xing;Zi Huimin;Tian Qiang(Yunnan Yuntianhua Co.,Ltd.R&D Center,Kunming 650228,China;School of Chemistry and Engineering,Kunming University of Science and Technology,Kunming 650093,China)

机构地区：[1]云南云天化股份有限公司研发中心,云南昆明650228 [2]昆明理工大学化学工程学院,云南昆明650093

出　　处：《云南化工》2024年第8期33-36,共4页Yunnan Chemical Technology

摘　　要：3-氯4-氟苯胺作为氟哌酸、西他沙星、阿法替尼等药物的重要的合成原料,其需求及生产规模逐年增加。介绍了3-氯4-氟苯胺的合成技术的进展,对其应用前景、合成路线、具体步骤的用料、反应进度差异进行了例举,对医药农药中间体3-氯-4-氟苯胺的合成分类进行了叙述。针对不同原料、合成措施及实验方法的优缺点等进行了总结,为后续实验探究提供参考。The demand of 3-chlorine 4-floanidine as an important synthetic raw material of fluflox,citafloxacin,afatinib,and its production scale increase year by year.This article provides an overview of the advancements in the synthesis technology of 3-chloro-4-fluoraniline,including its application prospects,synthesis routes,specific materials used in each step,and variations in reaction progress.Furthermore,it delves into the synthetic classification of 3-chloro-4-fluoraniline as a pharmaceutical pesticide intermediate.The advantages and disadvantages of different raw materials,synthetic measures and experimental methods are summarized to provide reference for the follow-up experimental research.

关 键 词：3-氯-4-氟苯胺 硝化 氟化 还原 合成 

分 类 号：TQ460[化学工程—制药化工]