磷氰酸阴离子在化学合成中的应用  

Application of 2-Phosphaethynolate Anion in Synthetic Chemistry

作　　者：童梦楠 罗永安 管小军 吴翊乐 胡英 赵玉芬 TONG Meng-nan;LUO Yong-an;GUAN Xiao-jun;WU Yi-le;HU Ying;ZHAO Yu-fen(School of Pharmacy,Zhejiang Pharmaceutical University,Ningbo 315100,China;Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences,Institute of Drug Discovery Technology,Ningbo University,Ningbo 315211,China)

机构地区：[1]浙江药科职业大学药学院,浙江宁波315100 [2]宁波大学新药技术研究院天体化学与空间生命-钱学森空间科学协同研究中心,浙江宁波315211

出　　处：《化学试剂》2024年第9期66-80,共15页Chemical Reagents

基　　金：浙江省教育厅一般项目(Y202250085);浙江药科职业大学校级项目(2021181)。

摘　　要：磷氰酸阴离子(OCP-)作为氰酸盐离子(OCN-)的等电体,两者在反应活性上存在明显差异。自1992年OCP-结构首次确认以来,如何安全、简便、经济、环保地合成稳定的OCP-化合物并对该物质及其衍生物的活性进行研究一度成为磷化学研究的热点。综述了OCP-的合成研究进展以及其在金属有机化学、小分子活化等领域中的反应活性研究,旨在为推动OCP-参与的相关活性研究,为其在小分子气体转化应用、催化剂设计、材料化学等多领域的研究做出贡献。同时,由于OCP-可以作为合成子用于构筑多种多样的含磷有机化合物,因此可以为药物研发领域提供新的候选分子。As an isoelectronic analog of the cyanate ion(OCN-),2-Phosphaethynolate anion(OCP-)shows significant different reactivity with its nitrogen analogue.Since the molecular structure of OCP-was first confirmed in 1992,the challenge of synthesizing stable OCP-compounds safely,simply,economically,and environmentally has become a major focus in phosphorus chemistry research.The progress in the synthesis of OCP-and its application in organometallic chemistry and small molecule activation were discussed.We aim to promote reactivity study of OCP-,as well as its applications in greenhouse gas conversion,organic catalysis and materials chemistry.Additionally,since OCP-can be used as a building block for constructing a variety of phosphorus-containing organic compounds,it also offers new potential drug candidates for pharmaceutical research.

关 键 词：磷氰酸阴离子 主族元素化学 磷化学 杂环 小分子活化 

分 类 号：O65[理学—分析化学]