益气固本汤联合运动干预对糖尿病模型大鼠血糖的调节  

Effect of Yiqi Guben Decoction Combined with Exercise Intervention on the Regulation of Blood Glucose in diabetes Model Rats

作　　者：苏虹霞 段玉红 张艳 高岩 白先 陈耀 雷霆 SU Hongxia;DUAN Yuhong;ZHANG Yan;GAO Yan;BAI Xian;CHEN Yao;LEI Ting(Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China)

机构地区：[1]陕西中医药大学附属医院,陕西咸阳712000

出　　处：《陕西中医药大学学报》2024年第5期24-29,共6页Journal of Shaanxi University of Chinese Medicine

基　　金：咸阳市科技局科研计划项目(2019k02-95)。

摘　　要：目的探究益气固本汤对糖尿病模型大鼠的血糖调节作用,并进一步研究其对血糖调节激素水平的影响。方法使用高脂饲料及链脲霉素建立糖尿病大鼠模型,实验设置运动组、益气固本汤组及益气固本汤+运动组,观察运动组、益气固本汤+运动组对糖尿病大鼠一般情况、空腹血糖(FBG)、空腹胰岛素水平、胰高血糖素水平、皮质醇及肝糖原水平的影响。结果与模型组比较,运动组、益气固本汤组及益气固本汤+运动组大鼠FBG,血清胰高血糖素、皮质醇水平降低显著,差异具有统计学意义(P<0.01,P<0.05);空腹胰岛素及肝糖原水平升高,差异具有统计学意义(P<0.01,P<0.05),益气固本汤+运动组对大鼠FBG,空腹胰岛素水平、胰高血糖素水平、皮质醇及肝糖原水平改变有协同作用(P<0.05)。结论益气固本汤联合运动干预可有效改善糖尿病大鼠其一般状态,降低糖尿病大鼠血糖并维持其血糖稳态,对糖尿病大鼠胰岛功能具有恢复作用。这可能与益气固本汤增加胰岛素分泌、降低及调节血清胰高血糖素和皮质醇分泌、增加肝糖原含量有关。Objective To explore the effect of Yiqi Guben Decoction on blood glucose regulation in diabetes model rats,and further study its effect on the level of blood glucose regulating hormone.Methods The model of diabetes rats was established with high-fat diet and streptozotocin.The experiment was set up with exercise group,Yiqi Guben decoction group and Yiqi Guben decoction+exercise group.The effects of exercise group,Yiqi Guben decoction+exercise group on the general situation,fasting blood glucose(FBG),fasting insulin level,glucagon level,cortisol and liver glycogen level of diabetes rats were observed.Results Compared with the model group,the exercise group,Yiqi Guben decoction group,and Yiqi Guben decoction+exercise group showed significant reductions in serum levels of glucagon and cortisol in FBg,with statistical significance(P<0.01,P<0.05).Fasting insulin and liver glycogen levels increased,with statistical significance(P<0.01,P<0.05).The Yiqi Guben decoction+exercise group had a synergistic effect on changes in FBg,fasting insulin levels,glucagon levels,cortisol and liver glycogen levels in rats(P<0.05).Conclusion Yiqi Guben decoction combined with exercise intervention can effectively improve the general state of diabetes rats,reduce the blood sugar of diabetes rats and maintain their blood sugar homeostasis,and have a recovery effect on the function of pancreatic islets of diabetes rats;This may be related to the fact that Yiqi Guben decoction increases insulin secretion,reduces and regulates serum glucagon and cortisol secretion,and increases liver glycogen content.

关 键 词：糖尿病 运动干预 血糖稳态 益气固本汤 益气养阴法 

分 类 号：R285.5[医药卫生—中药学]