表面修饰人工韧带以促进前交叉韧带重建后腱骨愈合的研究进展  

AResearch progress on superficial modification of artificial ligaments to promote tendon bone healing

作　　者：赵峥嵘 周鹏 田冬子 蔡茂林 刘登科 刘涛涛 高秋明 ZHAO Zhengrong;ZHOU Peng;TIAN Dongzi;CAI Maolin;LIU Dengke;LIU Taotao;GAO Qiuming(The First Clini-cal Medical College of Gansu University of Traditional Chinese Medicine,Lanzhou 730030,China;不详)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730030 [2]中国人民解放军联勤保障部队第九四〇医院骨科中心,兰州730050

出　　处：《实用医学杂志》2024年第17期2508-2512,共5页The Journal of Practical Medicine

基　　金：甘肃省青年科技基金(编号:22JR11RA005);军队专项培育计划项目(编号:2021yxky012)。

摘　　要：前交叉韧带(anterior cruciate ligament, ACL)损伤在膝关节韧带损伤中最常见,通常为强大暴力所致,其损伤破坏膝关节稳定性,可引起关节软骨的退变及半月板损伤,严重者将发展为骨性关节病。现阶段在关节镜下行前交叉韧带重建(anterior cruciate ligament reconstruction, ACLR)是治疗前交叉韧带(ACL)损伤的金标准,临床上多采用以聚对苯二甲酸乙二醇酯(pET)为材料的LARS(ligament advanced reinforcement system)人工韧带对损伤的前交叉韧带进行手术重建,随访中短期效果较好,但移植物与宿主骨隧道生物愈合较差,难以达到术后移植物真正“韧带化”要求。对人工韧带进行涂层修饰改性可改善其亲水性和生物相容性进而可促进移植物与骨隧道的愈合。本文就对人工韧带行表面修饰以促进ACLR后腱骨愈合的研究进展作一综述。Anterior cruciate ligament(ACL)injury is caused by strong violence,which can destabilize the knee joint,cause joint cartilage degeneration,meniscus injury,and in severe cases,develop osteoarthropathy.The gold standard for the treatment of ACLR injuries at this stage is arthroscopic anterior cruciate ligament recon-struction(ACLR).In clinical practice,the LARS(Ligament advanced reinforcement system)artificial ligament made of polyethylene terephthalate(PET)as the material has a good effect in the short and medium term,but the long-term biological healing between the graft and the host bone is poor,and the real"ligamentization"requirement of the postoperative graft cannot be met.Coating-modified modification of artificial ligaments can improve their hydrophilicity and biocompatibility,which in turn can promote the healing of graft-bone tunnels.Tendon bone healing is a bone-derived progressive process from indirect insertion to direct insertion,which takes a relatively long time and is closely related to the prognosis and early rehabilitation effect of patients.This article reviews the progress of superficial modification of artificial ligaments to promote ACLR tendon bone healing.

关 键 词：前交叉韧带损伤 LARS韧带 手术重建 表面修饰 腱骨愈合 

分 类 号：R686.5[医药卫生—骨科学]