食管鳞癌组织OTUD3和ILF2表达与临床病理特征及预后的关系  

Expression of OTUD3,ILF2 in esophageal squamous cell cancer tissue and their relationship with clinical pathological characteristics and prognosis

作　　者：余慧娟 辛勇 尹红英 赵家胜 李丽 YU Huijuan;XIN Yong;YIN Hongying;ZHAO Jiasheng;LI Li(First Clinical Medical College,Xuzhou Medical University,Xuzhou,Jiangsu 221000,China;Department of Oncology,Huai′an Fifth People′s Hospital,Huai′an,Jiangsu,223300,China)

机构地区：[1]徐州医科大学第一临床医学院,江苏徐州221000 [2]淮安市第五人民医院肿瘤科,江苏淮安223300

出　　处：《国际检验医学杂志》2024年第17期2098-2102,共5页International Journal of Laboratory Medicine

基　　金：江苏省卫生健康委科研课题(BJ19037)。

摘　　要：目的探究食管鳞癌组织OTU去泛素酶3(OTUD3)、白细胞介素增强结合因子2(ILF2)表达与临床病理特征及预后的关系。方法选取2019年1月至2020年7月在淮安市第五人民医院行食管癌根治术治疗的102例食管鳞癌患者作为研究对象。应用免疫组织化学检测组织OTUD3、ILF2表达。Spearman秩相关分析食管鳞癌中OTUD3与ILF2表达的关系。Kaplan-Meier生存曲线分析OTUD3、ILF2表达对食管鳞癌预后的影响。COX比例风险模型分析食管鳞癌预后影响因素。结果与癌旁组织相比,食管鳞癌组织中OTUD3阳性率较低,ILF2阳性率较高,差异均有统计学意义(P<0.05)。癌组织中OTUD3和ILF2表达呈负相关(r=-0.712,P<0.001)。相比于TNM分期Ⅰ~Ⅱ期、中高分化程度、无淋巴结转移食管鳞癌患者,TNM分期Ⅲ期、低分化程度、有淋巴结转移食管鳞癌患者组织OTUD3阳性率较低,ILF2阳性率较高,差异有统计学意义(P<0.05)。OTUD3阳性组患者3年累积生存率高于OTUD3阴性组,差异有统计学意义(Log-rank χ^(2)=5.869,P=0.015);ILF2阳性组患者3年累积生存率低于ILF2阴性组,差异有统计学意义(Log-rank χ^(2)=16.257,P<0.001)。TNM分期、淋巴结转移、分化程度、OTUD3及ILF2是影响食管鳞癌患者预后的独立因素。结论食管鳞癌组织OTUD3表达降低,ILF2表达升高,均参与食管鳞癌肿瘤的恶性进展,是影响食管鳞癌患者预后的独立因素。Objective To investigate the expression of OTU deubiquitinase 3(OTUD3)and interleukin enhancer binding factor 2(ILF2)in esophageal squamous cell cancer and their correlation with clinicopathological characteristics and prognosis.Methods A total of 102 patients with esophageal squamous cell cancer who underwent radical resection in Huai′an Fifth People′s Hospital between January 2019 and July 2020 were included in this study.Immunohistochemistry was used to detect OTUD3 and ILF2 expression.Spearman rank correlation analysis was conducted to assess the relationship between OTUD3 and ILF2.Kaplan-Meier survival curves were used to analyze the impact of OTUD3 and ILF2 expression on patient survival prognosis.COX regression analysis was employed to identify prognostic factors.Results Compared with adjacent tissues,the positive rate of OTUD3 was lower and the positive rate of ILF2 was higher in esophageal squamous cell cancer tissues,and the differences were statistically significant(P<0.05).A significant negative correlation was observed between the expression of OTUD3 and ILF2 in esophageal squamous cell cancer(r=-0.712,P<0.001).Furthermore,patients with TNM stageⅢ,low differentiation,and lymph node metastasis exhibited a lower positive rate of OTUD3 and a higher positive rate of ILF2 compared to patients with TNM stageⅠ-Ⅱ,medium-high differentiation,and no lymph node metastasis(P<0.05).The 3-year survival rate for the OTUD3-positive group was significantly higher than that of the OTUD3-negative group(Log-rankχ^(2)=5.869,P=0.015).The 3-year survival rate for the ILF2-positive group was significantly lower than that of the ILF2-negative group(Log-rankχ^(2)=16.257,P<0.001).TNM staging,lymph node metastasis,degree of differentiation,OTUD3,and ILF2 were independent factors affecting the prognosis of esophageal squamous cell cancer patients.Conclusion Decreased expression of OTUD3 and increased expression of ILF2 in esophageal squamous cell cancer tissues are implicated in the malignant progression of esophagea

关 键 词：食管鳞癌 OTU去泛素酶3 白细胞介素增强结合因子2 预后 

分 类 号：R446.1[医药卫生—诊断学] R735.1[医药卫生—临床医学]