血清sOSCAR对急性非ST段抬高型急性心肌梗死患者PCI术后心血管不良事件的预测价值  

Predictive value of serum sOSCAR for cardiovascular adverse events after PCI in patients with acute non-ST segment elevation acute myocardial infarction

作　　者：马文超 王琨 王小龙[1] 谢地成 刘磊[1] 孙胜 苏方成[1] MA Wenchao;WANG Kun;WANG Xiaolong;XIE Decheng;LIU Lei;SUN Sheng;SU Fangcheng(Department of Emergency,Weifang People′s Hospital,Weifang,Shandong 261000,China;Department of Respiratory and Critical Care Medicine,Weifang People′s Hospital,Weifang,Shandong 261000,China)

机构地区：[1]潍坊市人民医院急诊内科,山东潍坊261000 [2]潍坊市人民医院呼吸与危重症医学科,山东潍坊261000

出　　处：《国际检验医学杂志》2024年第17期2108-2112,共5页International Journal of Laboratory Medicine

基　　金：山东省医药卫生科技发展计划(2019WS21);潍坊市科研项目(WFWSJK-2023-332)。

摘　　要：目的探讨血清可溶性破骨细胞相关受体(sOSCAR)对急性非ST段抬高型急性心肌梗死(NSTEMI)患者经皮冠状动脉介入治疗(PCI)术后心血管不良事件的预测价值。方法选取2020年1月至2022年1月潍坊市人民医院收治的接受PCI术的124例NSTEMI患者为NSTEMI组,根据术后是否发生主要不良心血管事件分为预后不良组(n=31)和预后良好组(n=93),另选取同期100体检健康的志愿者为对照组。构建多因素Logistic回归模型分析影响NSTEMI患者PCI术后预后的因素,绘制受试者工作特征(ROC)曲线分析sOSCAR水平对NSTEMI患者PCI术后预后的预测价值。结果与对照组比较,NSTEMI组血清血管生成素-2(Ang-2)水平升高,sOSCAR水平降低(P<0.05)。随访1年,124例NSTEMI患者PCI术后预后不良发生率为25.00%(31/124)。多因素Logistic回归分析结果显示,年龄增加和Ang-2升高为NSTEMI患者PCI术后预后的独立危险因素(P<0.05),左心室射血分数升高和sOSCAR升高为独立保护因素(P<0.05)。ROC曲线分析显示,血清Ang-2、sOSCAR水平联合预测NSTEMI患者PCI术后预后的曲线下面积为0.865,大于血清Ang-2、sOSCAR水平单独预测的0.791、0.786(P<0.05)。结论NSTEMI患者血清sOSCAR水平与患者PCI术后预后不良密切相关,血清sOSCAR联合Ang-2对NSTEMI患者PCI术后预后不良有较高的预测价值。Objective To explore the predictive value of serum soluble osteoclast-associated receptor(sOSCAR)for cardiovascular adverse events after percutaneous coronary intervention(PCI)in patients with acute non-ST segment elevation acute myocardial infarction(NSTEMI).Methods From January 2020 to January 2022,124 NSTEMI patients admitted to Weifang People′s Hospital who underwent PCI were selected as the NSTEMI group,and another 100 healthy volunteers in the same period were selected as the control group.The NSTEMI patients were classified into 31 cases of poor prognosis and 93 cases of good prognosis group according to whether major adverse cardiovascular events occurred 1 year after PCI.Multivariate Logistic regression model was constructed to analyze the factors affecting the prognosis of NSTEMI patients after PCI,and receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of sOSCAR level on the prognosis of NSTEMI patients after PCI.Results Compared with the control group,serum angiopoietin-2(Ang-2)levels were increased and sOSCAR levels were decreased in the NSTEMI group(P<0.05).At 1-year follow-up,the incidence of poor prognosis after PCI in 124 NSTEMI patients was 25.00%(31/124).Multivariate Logistic regression analysis showed that increasing age and Ang-2 were independent risk factors affecting the prognosis after PCI in patients with NSTEMI(P<0.05),and elevated left ventricular ejection fraction and elevated sOSCAR were independent protective factors(P<0.05).ROC curve analysis showed that the area under the curve of serum Ang-2 and sOSCAR levels combined to predict the prognosis after PCI in NSTEMI patients was 0.865,which was greater than that of serum Ang-2 and sOSCAR levels alone,which were 0.791 and 0.786(P<0.05).Conclusion Serum sOSCAR level is decreased in patients with NSTEMI and is closely related to the poor prognosis of patients after PCI.Serum sOSCAR combined with Ang-2 has a high predictive value for the poor prognosis of NSTEMI patients after PCI.

关 键 词：急性非ST段抬高型心肌梗死 血管生成素-2 可溶性破骨细胞相关受体 经皮冠状动脉介入治疗 预后 

分 类 号：R446.1[医药卫生—诊断学] R543.3[医药卫生—临床医学]