STING、ZEB1在老年宫颈癌患者中的表达及与HPV感染的相关性  

Changes in STING and ZEB1 protein levels in elderly cervical cancer patients and their correlation with HPV infection

作　　者：张林光 董涛[1] 印海娟 刘亚丽[1] ZHANG Linguang;DONG Tao;YIN Haijuan;LIU Yali(Physical Examination Center,Qinhuangdao First Hospital,Qinhuangdao,Hebei 066000,China)

机构地区：[1]秦皇岛市第一医院体检中心,河北秦皇岛066000

出　　处：《国际检验医学杂志》2024年第17期2117-2120,共4页International Journal of Laboratory Medicine

基　　金：秦皇岛市科学技术研究与发展计划(202301A232)。

摘　　要：目的探讨干扰素基因刺激因子(STING)、E盒锌指结合蛋白1(ZEB1)在老年宫颈癌(CCA)患者中的表达变化及与人乳头瘤病毒(HPV)感染的相关性。方法选取2021年1月至2022年9月于该院行病理检验的CCA患者62例为CCA组,宫颈上皮内瘤变(CIN)患者65例为CIN组,正常宫颈者63例为对照组,观察记录各组患者宫颈STING、ZEB1阳性表达率及高危HPV感染情况,并分析STING、ZEB1水平与CCA临床病理特征及高危HPV感染情况的相关性。结果CCA组STING、ZEB1阳性表达率高于CIN组及对照组,CIN组ZEB1水平高于对照组,差异均有统计学意义(P<0.05)。CCA组HPV16、18检出率高于CIN组及对照组,CIN组HPV16、18检出率高于对照组,差异均有统计学意义(P<0.05)。CCA患者浸润深度、国际妇产科联盟(FIGO)分期与STING、ZEB1阳性表达率有关(P<0.05),肿瘤分化程度、淋巴结转移与STING阳性表达率有关(P<0.05),CCA患者STING、ZEB1阳性表达率与HPV16、18感染率呈正相关(P<0.05)。结论CCA患者STING、ZEB1阳性表达较高其表达量与FIGO分期、宫颈癌浸润深度、HPV16、18感染有关。STING、ZEB1可能与HPV16、18共同作用于CCA的发生、发展。Objective To investigate the expression changes of interferon gene stimulating factor(STING)and E-box zinc finger binding protein 1(ZEB1)in elderly cervical cancer(CCA)patients and their correlation with human papillomavirus(HPV)infection.Methods Sixty-two patients with CCA who underwent pathological examination in this hospital from January 2021 to September 2022 were selected as the CCA group,65 patients with cervical intraepithelial neoplasia(CIN)as the CIN group,and 63 patients with normal cervix as the control group.The positive expression rates of cervical STING and ZEB1 and high-risk HPV infection in each group were observed and recoraded.The correlation of STING and ZEB1 levels with clinicopathological features of CCA and high-risk HPV infection was analyzed.Results The positive expression rates of STING and ZEB1 in CCA group were higher than those in CIN group and control group,and the level of ZEB1 in CIN group was higher than that in control group,with statistical significance(P<0.05).The detection rates of HPV16 and 18 in CCA group were higher than those in CIN group and control group,and the detection rates of HPV16 and 18 in CIN group were higher than those in control group,the differences were statistically significant(P<0.05).The infiltration depth and FIGO stage of CCA patients were correlated with the positive expression rates of STING and ZEB1,the degree of tumor differentiation and lymph node metastasis were correlated with the positive expression rates of STING(P<0.05),and the positive expression rates of STING and ZEB1 in CCA patients were positively correlated with the infection rates of HPV16 and 18(P<0.05).Conclusion The positive expression levels of STING and ZEB1 proteins in the CCA group are higher than those in the control group and CIN group,and their expression levels were related to FIGO staging and depth of cervical cancer infiltration.STING and ZEB1 proteins are positively correlated with HPV16 and 18 infection,and STING and ZEB1 proteins may jointly act with HPV16 and 18 on the

关 键 词：宫颈癌 干扰素基因刺激因子 E盒锌指结合蛋白1 人乳头瘤病毒 

分 类 号：R446.1[医药卫生—诊断学] R737.33[医药卫生—临床医学]