血清BHLHE40水平与2型糖尿病亚临床动脉粥样硬化的关系  

Correlation between serum BHLHE40 levels and subclinical atherosclerosis in type 2 diabetes mellitus

作　　者：殷兆芳 吕晴 崔晶刚 YIN Zhaofang;LYU Qing;CUI Jinggang(Department of General Practice,Suzhou Municipal Hospital,Suzhou,Jiangsu 215001,China;Department of Respiratory and Critical Care Medicine,Suzhou Municipal Hospital,Suzhou,Jiangsu 215001,China)

机构地区：[1]苏州市立医院全科医学科,江苏苏州215001 [2]苏州市立医院呼吸与危重症医学科,江苏苏州215001

出　　处：《国际检验医学杂志》2024年第17期2127-2131,共5页International Journal of Laboratory Medicine

基　　金：江苏基层卫生发展与全科医学教育研究中心重点项目(2021A01);2022年度苏州市“科教兴卫”青年科技立项项目(KJXW2022034);2020年度苏州市临床重点病种诊疗技术专项(LCZX202012)。

摘　　要：目的探讨血清基本螺旋-环-螺旋家族成员E40(BHLHE40)水平与2型糖尿病(T2DM)亚临床动脉粥样硬化(SAS)的关系。方法选取2021年1月至2023年1月苏州市立医院全科医学科收治的145例T2DM患者为研究对象。根据患者是否发生SAS分为SAS组(n=80)和未发生SAS组(n=65)。比较两组患者血清BHLHE40水平及临床资料,采用Pearson相关分析患者血清BHLHE40水平与颈动脉内膜中膜厚度(CIMT)的相关性,采用多因素Logistic回归分析T2DM患者发生SAS的危险因素,采用受试者工作特征(ROC)曲线分析血清BHLHE40水平诊断T2DM患者发生SAS的价值。结果SAS组年龄、糖尿病病程、低密度脂蛋白胆固醇(LDL-C)、CIMT及血清BHLHE40水平高于未发生SAS组,差异有统计学意义(P<0.001)。相关性分析结果显示,血清BHLHE40水平与CIMT呈正相关(r=0.671,P<0.001)。多因素Logistic回归分析结果显示,糖尿病病程、年龄、CIMT、LDL-C、血清BHLHE40水平均是T2DM患者发生SAS的危险因素(P<0.05)。ROC曲线分析显示,血清BHLHE40诊断T2DM患者发生SAS的曲线下面积(AUC)为0.742,灵敏度为75.0%,特异度为73.9%。结论血清BHLHE40水平与T2DM患者发生SAS密切相关,对T2DM患者发生SAS具有诊断价值。Objective To investigate the correlation between serum basic helix-loop-helix transcription factor family member E40(BHLHE40)levels and subclinical atherosclerosis(SAS)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 145 T2DM patients admitted to the Department of General Practice of Suzhou Municipal Hospital from January 2021 to January 2023 were selected as the study objects.Patients were divided into SAS group(n=80)and non-SAS group(n=65)according to whether SAS occurred.Serum BHLHE40 level and clinical data of the two groups were compared.The correlation between serum BHLHE40 level and carotid intima media thickness(CIMT)was analyzed by Pearson correlation.The risk factors of SAS in T2DM patients were analyzed by multi-factor Logistic regression.The value of serum BHLHE40 level in the diagnosis of SAS in T2DM patients was analyzed by receiver operating characteristic(ROC)curve.Results The age,duration of diabetes,low-density lipoprotein cholesterol(LDL-C),CIMT and serum BHLHE40 levels in SAS group were significantly higher than those in non-SAS group,with statistical difference(P<0.001).Correlation analysis showed that serum BHLHE40 level was positively correlated with CIMT(r=0.671,P<0.001).Multivariate Logistic regression analysis showed that duration of diabetes,age,CIMT,LDL-C and serum BHLHE40 level were all risk factors for SAS in T2DM patients(P<0.05).ROC curve analysis indicated that the area under the curve(AUC)of serum BHLHE40 for the diagnosis of SAS in T2DM patients was 0.742,the sensitivity was 75.0%,and the specificity was 73.9%.Conclusion Serum BHLHE40 expression level is closely related to the occurrence of SAS in T2DM patients,and is of great diagnostic value for the occurrence of SAS in T2DM patients.

关 键 词：基本螺旋-环-螺旋家族成员E40 2型糖尿病 亚临床动脉粥样硬化 

分 类 号：R446.1[医药卫生—诊断学] R587.1[医药卫生—临床医学]