猪德尔塔冠状病毒致病机理研究进展  

Research progress on pathogenesis of porcine deltacoronavirus

作　　者：石迎 陶洁[1] 李本强[1] 程靖华[1] 刘惠莉[1] SHI Ying;TAO Jie;LI Benqiang;CHENG Jinghua;LIU Huili(Institute of Animal Husbandry and Veterinary Science,Shanghai Academy of Agricultural Sciences,Shanghai Key Laboratory of Agricultural Genetic Breeding,Shanghai Engineering Research Center of Pig Breeding,Shanghai 201106,China)

机构地区：[1]上海市农业科学院畜牧兽医研究所,上海市农业遗传育种重点实验室,上海市种猪工程技术中心,上海201106

出　　处：《上海农业学报》2024年第4期127-134,共8页Acta Agriculturae Shanghai

基　　金：上海市青年科技英才扬帆计划(21YF1441300)。

摘　　要：猪德尔塔冠状病毒(Porcine deltacoronavirus,PDCoV)是流行于猪群中的一种新发肠道冠状病毒,能引起猪腹泻、呕吐、脱水甚至死亡,给养猪业带来巨大威胁。PDCoV可在猪、禽类和牛体内复制,甚至在人体血浆样品中检出,具有潜在的公共安全问题,存在引发大流行的威胁,深入开展PDCoV的致病机理研究对该病的防控有重要意义。本文从其入侵宿主细胞以拮抗干扰素反应、诱导细胞凋亡、调控细胞自噬、抑制细胞焦亡途径来逃避宿主免疫应答,以及其他影响PDCoV复制的分子机制方面对其致病机理进行总结,为后续科学研究和有效防治提供借鉴。Porcine deltacoronavirus(PDCoV)is a new enteropathogenic coronavirus that has been prevalent in pigs.It can cause diarrhea,vomiting,dehydration and even death in pigs,which poses a great threat to the pig industry.PDCoV can replicate in pigs,poultry and calves,and even can be detected in human plasma,poseing a potential threat to public health.Therefore,it is important to carry out in-depth research on the pathogenesis of PDCoV for its prevention and control.The author summarized the progress of PDCoV pathogenesis from the aspects of its invasion into host cells,antagonism of interferon reaction,inducing cell apoptosis,regulating cell autophagy,inhibiting cell pyrolytic pathway to escape host immune response,and other molecular mechanisms that affected the replication of PDCoV,which would provide reference for subsequent scientific research and effective prevention.

关 键 词：猪 德尔塔冠状病毒 致病机理 研究进展 

分 类 号：S852.651[农业科学—基础兽医学]